RI 3617 Methanol Poisoning - 1 Exposure to Dogs to 450-500 P.P.M. Methanol Vapor in Air

"This report is the first of a series dealing with the results of a comprehensive investigation of methanol poisoning, conducted jointly by the Federal Bureau of Mines, Carbide & Carbon Chemicals Corporation, du Pont Ammonia Corporation, and the Commercial solvents Corporation.The study dealt mainly with physiological effects produced by inhalation of methanol vapor, and concentration studied ranged from approximately 500 to 15,000 p.p.m., and periods of exposure from 4 hours daily to continuous. The range of concentrations and periods of exposure were such as to produce acute effects, with and without fatalities, by a singel exposure and chronic poisoning, with and without fatalities, as well as little or no response after repeated daily exposures. In addition to the inhalation experiments, skin absorption was studied, and field surveys were made to ascertain the hazards associated with the manufacture and, use of methanol."