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By Peter J. Barnard

Mitochondria play a key role in the regulation of apoptosis (cell death) and in diseases characterised by abnormal apoptotic responses such as cancer. Mitochondrial membrane permeabilisation (MMP), regulated by the mitochondrial permeability transition pore complex, is widely accepted as being central to the process of cell death. As a result there has been considerable recent interest in targeting mitochondrial cell death pathways in the development of new chemotherapeutic agents.(1) There is potential to overcome the two overriding problems in cancer chemotherapy?the common occurrence of drug-resistant tumour cells and the lack of selectivity of cancer drugs in differentiating between tumour cells and normal tissues. Significantly, carcinoma cells have an elevated mitochondrial membrane potential relative to normal cells and lipophilic cations are concentrated within mitochondria in response to mitochondrial membrane potentials. There is potential for the selective targeting to tumour cells with compounds having optimal lipophilic-hydrophilic character. Research stemming from the early 1980?s points to two distinct classes of Au(I) phosphine antitumour agents where an antimitochondrial mode of action has been implicated: (i) neutral linear two-coordinate Au(I) complexes such as triethylphosphinegold(I) chloride and the tetraacetylthioglucose gold(I) phosphine complex, Auranofin; (ii) cationic tetrahedral bis-chelated Au(I) phosphine complexes related to [Au(dppe)2]+.(2) Recently it has been reported that Auranofin, at submicromolar concentrations, induces MMP observed as mitochondrial swelling and dissipation of membrane potential.(3, 4) Both events are completely inhibited by cyclosporin-A, the specific inhibitor of MMP. The permeability changes were shown to occur at concentrations associated with the selective inhibition of mitochondrial thioredoxin reductase.(3) Auranofin is a potent and specific inhibitor of this enzyme due to Au(I) binding to the active-site selenol group.(5) The redox state of mitochondrial thiols may be critical in the control of MMP.(3) In general, swelling is stimulated by thiol blocking or oxidising agents and is prevented by thiol reducing agents.(1) Mitochondrial thioredoxin reductase may play an import role in the redox control of the permeability of mitochondrial membranes.(3) Our interest is in investigating the antitumour potential of Au(I) phosphine compounds using a number of different approaches. In recent work we have evaluated a series of hydrophilic analogs of [Au(dppe)2]+ containing pyridylphosphine ligands which have demonstrated greater tumour selectivity than the parent compound. To investigate the possible antimitochondrial mode of action we are studying the effect of [Au(dppe)2]+ and related compounds on isolated rat liver mitochondria. To assess whether the lipophiliccationic nature of the compounds determines the antitumour activity, we have synthesized a series of novel Au(I) complexes based on heterocyclic carbene rather than phosphine ligands. The similar chemistry and structural features of the two classes of complexes allow us to assess whether the phosphine ligands are essential for the antitumour properties.

Oct 1, 2003

By U. Storck

"Shaft sinking for exploitation of the deep potash beds in Saskatchewan involved great difficulties from the very first because of the need to exclude from the shaft the high-pressure water encountered in the overburden. Control of the troublesome Blairmore quicksands was achieved relatively quickly by use of the freezing method and by lining with cast iron tubbing. The unsolved problem remained, however, of sealing the water-bearing Devonian where the formations had extremely low permeability and were thus hard to grout. Long experience in German potash mines had shown that the permanency of the whole mine would be seriously endangered if large amounts of unsaturated salt water were allowed to flow in from the shaft wall and merely removed by pumping. The prevention of water movement and the resulting dissolution of salt in the overburden were known to be most important. In the Alwinsal shaft, water flow from the Devonian has been prevented by the use of a steel and concrete sandwich lining similar in principle to a kind of lining introduced a few years earlier, and for another reason, in German coal shafts. As its installation is neither more expensive nor more time consuming than that of cast iron tubbing lining, this same lining was also chosen as protection against the Blairmore quicksands. The great advantage of the steel lining, in addition to its relatively high strength, is the fact that it is possible to make the joints of the individual segments absolutely and permanently water-tight by means of tested welds. The virtual dryness of the Alwinsal shaft will also result in lower costs because significant corrosion of all its steel installations, including skips, cage and ropes, will be prevented."

Jan 1, 1968

In most instances, the preferred mining methods in steeply dipping narrow vein deposits are selective methods such as cut and fill or shrinkage. The main advantage of these methods lies in the higher degree of control over dilution that can be achieved. However, where ore body geometry lends itself to it, high yield bulk methods can also be attractive. Higher productivity (and the associated lower costs) and lower worker exposure are some of the significant advantages that have made such methods so popular. The Lapa gold mine located in North-Western Quebec uses the long hole mining method (with cemented rock fill) very successfully despite challenging ground conditions. This paper focuses on the experience of the mine with regards to drilling and blasting practices. Firstly, the reasons that prompted the selection of this mining method at Lapa are examined. Secondly, the challenges that the difficult ground conditions found at Lapa pose to drilling and blasting are discussed. Finally, the results of trials of different drilling and blasting strategies that were performed at the mine are presented with particular emphasis on the lessons learned.

Aug 1, 2013

By V. T. Panayotov, M. I. Panayotova

Wastewater from mining and mineral processing activities is often polluted by anion forming metals, such as molybdenum and chromium. Low cost materials, including zeolites, are studied for removing heavy metals from wastewater. It is widely accepted that natural zeolites are not effective in removing metals in anionic form. The paper presents study on use of metal modified natural clinoptilolite to remove Mo (VI) and Cr (VI) ions from model soft wastewater. Modification with Pb, Fe(III), Zn and Ba increases clinoptilolite uptake capacity with respect to Mo(VI) at low pH values of the water subjected to treatment, the efficiency decreasing in the order Pb > Fe(III) > Zn > Ba. Only lead-modified clinoptilolite shows high uptake of Mo(VI) in acidic, neutral and slightly alkaline conditions. Modification with Pb, Ba and Fe(III) increases zeolite uptake capacity with respect to Cr(VI) from neutral water. The effectiveness of Ba-modified zeolite decreases in slightly acidic water. Over 90 % uptake of initially available Cr(VI) is achieved by lead-modified clinoptilolite both under neutral and slightly acidic conditions. Increasing the initial pollutant concentrations increases the removed amount both of Cr(VI) and Mo(VI) for Pb-modified clinoptilolite. The findings could be a basis for using the natural clinoptilolite to remove in consecutive steps: firstly Pb(II) and/or Fe(III) ions and then loaded zeolite to be used for Mo (VI) and/or Cr(VI) removal. The kinetics of Mo(VI) uptake by CL-Ba, CL-Fe(III), CL-Pb, and CL-Zn is best described by the pseudo-first order kinetic equation. The kinetics of Cr(VI) removal by CL-Ba, CL-Fe (II), CL-Fe (III) and CL-Zn is best described by the pseudo-first order kinetic equation. Kinetics of Cr(VI) removal by CL-Pb obeys the equation for the first order irreversible reactions. Finding way to remove anions-pollutants from the mineral processing wastewater will render this industry more environmentally friendly and socially acceptable.

Jan 1, 2016

By J. Lee

As the usage of BIM increased in the construction industry, some construction owners started exploring the use of BIM for maintaining their facilities. Construction Operations Building Information Exchange (COBIE), a spreadsheet data format suggested in 2007 to manipulate building information, is considered as one of the solutions that would facilitate the process of transferring information from BIM to applications for facilities management. Several BIM and Computer Aided Facilities Management (CAFM) applications offer functions to export or import the COBIE data. To facilitate the process of generating the COBIE data out of Building Information Model, some add-in applications, such as COBIE Toolkit for Revit, also were developed. However, most of these applications handle a limited amount of COBIE data. Professionals using these add-in applications therefore sometimes end up spending a significant amount of time to add additional data manually to the COBIE data file. To automatically get a data-rich COBIE file, we developed a prototype application that extracts information from Revit, which is one of the BIM authoring tools, stores them in an external database, and then produces the COBIE file using information stored in the database. We applied our application to a pilot project and produced 8 COBIE worksheets automatically, which demonstrated a significant amount of time saving. This paper presents how our prototype application produces 8 COBIE data sets automatically. It also addresses our attempt to handle more COBIE data sets.

Aug 1, 2013

By V. L. Mitsopoulos

This paper provides a summary of tailings disposal techniques and the improvements that have been made through the introduction of thickened tailings disposal. The general properties and characteristics of thickened tailings are described, as is a design process for selecting appropriate technologies for thickening, pumping, transporting and storing tailings. The factors affecting the selection of an appropriate disposal site and operational considerations for the effective utilisation of tailings storage areas are also documented.

Jan 1, 2006

By Staff

One hundred thousand miles of flying over the North country without a single air casualty; much of it over virgin territory probably never before visited by white men; some of it over regions that abound with possibilities for minerals; all of it effective, for exploration and the establishment of bases and supply-stations, and for the carrying of men and their tools and provisions- this, briefly, is the record of Northern Aerial Minerals Exploration, Limited, a Canadian company organized Jess than nine months ago, which has been functioning, without interruption, during spring, summer, and now into winter. Our planes have ranged from the Alaskan boundary on the west to the Labrador coast on the east, and from the Transcontinental railway north to the Arctic circle. Our prospectors, carried on trips of hundreds, and occasionally thousands, of miles, have gone over large sections of country which were never before explored, and at the end of the prospecting season the Company finds itself in possession of several groups of important gold claims, which look most promising. In addition to this, we have been in contact with deposits of almost every known mineral.

Jan 1, 1929

By Peter Hood

Data on world-wide geophysical activity in mining exploration programs are collected annually by the Society of Exploration Geophysicists' Geo-physical Activity Committee as part of a continuing service to the industry. The data are obtained by sending out questionnaires to all organizations which are known to be carrying out mining geophysical work; the organizations canvassed include mining companies, contractors, government departments and universities. The questionnaire is divided into three sections; namely, ground methods, airborne methods and research. The data compiled from the questionnaires show that world-wide utilization of mining geophysical methods reached a new high in 1967 with total expenditures of (U .S.) $32,323,240. This was divided as follows: ground methods, $18,106,785; airborne methods, $10,-123,405; and research, $4,093,050. For the ground methods, most money was spent on the induced polarization technique ($5,681,780); electromagne-tic methods were second in reported expenditures ($2,010,900). The total reported geophysical line mileage flown was 1,275,072 line miles, with aeromagnetic surveying being the most popular airborne method. The total amount spent on aeromagnetic surveys was $5,832,564 for 895,420 line miles. This gives an average cost of (U.S.)$6.50 per line mile.

Jan 1, 1968

By P. M. Dranchuk

"""PLANET EARTH seen from space appears as a fragile and limited life-supporting system in a vast emptiness. That such a view is, in fact, an accurate one is now more widely accepted than it was not long ago, before Earth's problems of over-population, overconsumption, limited resources and environmental degradation attained the limelight. The danger is that a government and public now deluged by doomsday prophecies and bemused by equally confident reiterations that technology will cure all may hesitate in coming to grips with the problem, in the hope that, given time, it will go away."" With these words, Preston Cloud begins a recent editorial, in Science(l), in which he presents a brief resume of some of the findings of the Committee on Resources and Man of the National Academy of Science-National Research Council(20.Their report, which is based on a two-year study by an extremely competent group and consists of some 250 pages of text, is even more far-reaching and sobering than the report on Energy Resources(3). It begins by quoting Sir Macfarlane Burnet as follows:""There are three imperatives: to reduce war to a minimum; to stabilize human population, and to pre-vent the progressive destruction of the earth's irreplaceable resources.(4)"

Jan 1, 1971

By G. R. Heffernan

"IntroductionTHE PURPOSE of this paper is to give a •brief history of iron and steel in British Columbia, a quick look at the present operations of Western Canada Steel, Limited, a review of iron ore resources and iron and steel markets, and a projection of what the future might hold for the industry in British Columbia.From the Past to the PresentWhile the paper is entitled Past, Present, and Future, in covering the past, which we shall call the time prior to 1947, there is very little to be said. Small shipments of iron ore were made from the Texada deposits by the Puget Sound Iron Company from 1886 to 1907. Total ore shipped did not exceed 70,000 tons. Part of this is believed to have been used in building a United States battleship in 1907 in the Bremerton Naval Yards in Seattle, Washington.In 1914 a small steel mill was started on Lulu island, rolling bars from •box piles and used shafting. This mill operated spasmodically for a few years but finally burned down in 1921. The rolling mill stands were sold to China and are no doubt in operation in China today.In 1916 the City of Port Moody assisted in the financing of a mill which operated on re-roll rails, box piles, and steel ingots made in an experimental electric furnace in Port Moody. This furnace also produced small quantities of pig iron scrap. The backers of the Port Moody mill showed a great deal of enterprise and must have been a very forward looking group, since this was one of the first recorded applications of the electric furnace to small ingot production. Despite their enterprise, the operation was unsuccessful and terminated in 1921."

Jan 1, 1953

By C. H. Knight

"THE OBSERVATIONS that follow are confined to simple wet cyclones such as the cylindro-conical unit developed by the Dutch States Mines and marketed in America under the trademark 'Dorr-Clone'. Energy to do the work comes from the inlet velocity of the feed slurry, which is usually pumped' to the unit by a centrifugal pump.Such cyclones are simply classifiers of enormous capacity and depend for their separating effect on differences in rates of particle settlement. These particle settling rates, of course, vary with particle size, particle density, particle shape, pulp viscosity, and pulp density.The dilution of the overflow product affects both pulp viscosity and pulp density. In most operations, the temperature and the composition of the liquid -hence its viscosity --are fixed, but both pulp viscosity and pulp density can be changed by changing pulp dilution.Since the separating effect depends on differences in rates of particle setting, a perfect split with 100 per cent of the particles coarser than a given size in the underflow and 100 per cent of the finer sizes in the overflow is not possible. Just how far the separation departs from this perfection can be calculated rather exactly from the following principles, which also apply to mechanical classifiers. In removing or settling out of the overflow product all particles up to a specified size, some of the finer particles must settle out simultaneously."

Jan 1, 1955

By Richard Dawson

Increasing global demand for coking coal has initiated several new coal mine developments in northeast BC. These developments are able to take advantage of the currently under utilized infrastructure that was put in place during the 1970?s and 1980?s for the Quintette and Bullmoose coal mines; which includes the Town of Tumbler Ridge, a 1,000km rail line to the coal terminal at Prince Rupert and a road system providing highway access to the town site. Coal within the two foothills regions of BC (north-east and south-east) is mined by open pit truck/shovel methods. Optimized mine plans require a thorough understanding of Rocky Mountain structural geology, attention for access in steep terrain, and a related understanding of the geotechnical conditions that control the stability of pit slopes and waste dumps. Thus there is a requirement to properly integrate mine planning with geotechnical engineering considerations. Many of the technical issues are well understood from experience during the past 30 years of Western Canadian coal mining. The challenge is to ensure that the mine plans are able to take full advantage of these lessons learned. The paper will focus on mine planning and geotechnical design issues to do with high angle-of-repose waste dumps and steeply bedded footwall slopes to illustrate the advantage of properly recognizing the important stability control issues during the early stages of engineering evaluations. Case histories from the existing and planned coal mining operations will be presented.

May 1, 2006

By R. A. Wyman, F. E. Hanes

THE demand for high-quality aggregate is increasing in all phases of the construction industry and in all organizations associated with road building in Canada. The production of aggregate in Canada has increased almost continuously since the end of the war and has quadrupled since 1948. Increases during the past fifteen years can be accounted for by the expansion in all types of construction, particularly that of roads and highways. Total construction in 1959, based on preliminary estimates, has been valued at $7 billion, and an increase fore-cast for 1960 indicates optimism on the •construction horizon (1). Cement produced in Canada in 1959 amounted to 6.3 million tons. This is more than 2.5 times the 1948 production. Increased cement production indicates an increased use of concrete, and thus an increased need for aggregate. Natural sand and gravel deposits are gradually being depleted.

Jan 1, 1962

By C. Doyle, J. Brennan, C. Díaz, J. Hrepic, K. Cushnie

"In 1991/1992, INCO undertook a successful R&D program aimed at extending the lining lives of the top blown rotary converters (TBRCs)at its Copper Cliff Nickel Refinery (CCNR) and the electric furnace at INMETCO. At the laboratory scale, this effort was divided into three phases. In the first part, mineralogical work was performed on six refractories that were either currently being used to line these vessels or were considered suitable alternatives. In the second part, this mineralogical knowledge was used to help determine the compositions of slags that would not corrode the bricks at the operating temperature (1600°C) of the above furnaces. Finally, several important properties of the six refractories were measured to complete their evaluation as candidate linings. This paper reports the results of all three phases of the laboratory scale R&D work.The mineralogical work showed that rebonded fused grain magnesite-chrome (RFG-MC) bricks consist principally of periclase with minor amounts of free chromite and trace quantities of silicates monticellite and sometimes olivine. The bricks are principally held together by periclase-periclase direct bonding. Of note, the bulk of the chromite exists as exsolved precipitated blebs within the periclase grains. These likely redissolve at high temperature.Slags on the periclase liquidus coexist stably with these refractories. Examples are presented using CaO-MgO-Al2O3-SiO2 slags at~1600°C.Finally, the two refractories manufactured using close to 100% fused grain material generally outperformed the others in terms of physical properties and certainly were superior in their resistance to slag penetration damage."

Jan 1, 1997

By K. Soldenhoff, M. Fainerman-Melnikova

The use of strong base resins for uranium recovery is severely affected by the presence of chloride ions in solution. In areas where high-quality process water is not readily available, the use of saline water would extend the potential application for ion exchange in uranium processing. This study presents measurements of uranium uptake, using a wide range of commercially available weak base anionic exchangers, from solutions with chloride concentrations ranging from 2.5 to 22 g/L Cl. Out of 14 weak base anionic resins tested, 3 were identified that were not severely impacted by the presence of chloride and significantly outperformed a gel strong base resin typically used for uranium recovery in high-chloride environments. The uranium loading was sufficiently high for the consideration of development of the application of uranium recovery from uranium ores leached with seawater.

Jan 1, 2012

By D. B. Dreisinger, M. R. Tavakoli

"Vanadium has been produced from a variety of sources. This metal is known to make aqueous solutions of complex speciation as a function of vanadium concentration and pH. Considering the method of leaching, the impurities in the pregnant leach solution, and the planned vanadium product, different extractants and flowsheets can be applied for solution purification. This paper reviews the purification of vanadium leaching solution using organophosphorus, solvating, and amine extractants. This review focuses on vanadium separation from iron, molybdenum, and uranium, which are often present in vanadium resources such as primary ores, fly ashes, and spent catalysts.RÉSUMÉ Le vanadium est produit à partir de diverses sources. Ce métal est connu pour permettre des solutions aqueuses de spéciations complexes en fonction de la concentration du vanadium et du pH. En tenant compte de la méthode de lixiviation, des impuretés dans la solution mère de lixiviation et du produit de vanadium planifié, divers agents d’extraction et schémas de traitement peuvent être mis en oeuvre pour purifier la solution. Le présent article étudie la purification de la solution de lixiviation du vanadium au moyen d’extractants organophosphorés, solvants et aminés. L’étude cible la séparation du vanadium du fer, du molybdène et de l’uranium, lesquels sont souvent présents dans les ressources de vanadium telles que les minerais primaires, les cendres volantes et les catalyseurs usés."

Jan 1, 2016

"IntroductionNOTE.-All figures on the supply and consumption of coal in Canada cited in this paper were collected and reported by the Dominion Bureau of Statistics. The friendly and efficient co-operation of the officials of the Bureau. is the foundation upon which it has been my privilege to rely in the preparation of this and two earlier papers ( 1). My thanks are due also to our own staff on the Dominion Coal Board, who spared neither time nor effort in helping to prepare this paper.STATISTICS are comparatively dull and, to many people, coal statistics are duller than most. Coal is, however, the one basic mineral upon which our whole way of life depends and it may be well if attention is drawn to this fact by an occasional statistical review of the coal position in Canada. The recent furore over the oil and gas discoveries has so obscured the basic position of coal in many minds that a little basic coal information may be useful. It is for this reason that, for the third successive year, a factual survey of the coal position is being presented.In the previous papers (1) explanations have been given of the basic considerations in the preparation of these reports and some special phases of the overall picture have been examined. For these explanations, the earlier papers may be consulted."

Jan 1, 1952

By G. R. Phare

Explosives formulation is dictated by desired field performance, which in turn is dependent on such physical properties as strength, velocity of detonation, sensitivity, and water resistance. The design of explosives to obtain these properties is discussed with some reference to detonation and rock mechanics theory.

Jan 1, 1958

By G. M. Brownell

Introduction Within the past year a new deposit of gypsum has been opened up and brought into production in the Province of Manitoba. Until 1930, Manitoba's entire production came from Gypsumville, northwest of Winnipeg, at mile 161 on the Gypsumville branch of the Canadian National railway. However, during 1930 a gypsum bed was opened up at a point one mile south of the village of Amaranth, forty miles north of Portage la Paririe, on the west side of lake Manitoba (See Figure 1). Although no exposure has yet been discovered, the presence of gypsum below the surface in that district has been known for many years as the result of drilling for water. In 1929, J. R. Spear (1), of Winnipeg, interested some local capital in the possibility of .finding commercial deposits of gypsum, and, after some exploration work in the area with a well drill, the Amaranth deposit was located. Sixteen holes were put down at intervals of 400 or 500 feet, all of which encountered what appeared to be a continuous bed of gypsum, about thirty-eight feet thick, at a depth of 92 feet. The extent of the deposit has not yet been determined.

Jan 1, 1931

By J. H. Fulton

Summary Considerable test work has been done with the detachable type of carbide bit. In general, these bits improved drilling operations, but at a bit cost .greater than was compensated for by the reduction in man-hours of labour. Too few bits continued in service for the possible drilling life of the carbide inserts, and technical improvements or lowered first cost, preferably .both, are indicated ?in order that the bits can be generally acceptable as an economical drilling tool. In ?preliminary test work, the drill rods .with ?one insert of the chisel-bit type appear to be more trouble-free, to have a longer life, and to give a somewhat lower bit cost per foot drilled, than other types. INTRODUCTION The object of this paper is to outline briefly the 'methods used and the results obtained in test work with tungsten carbide bits used in combination with the smaller bore, lighter weight rock drills. As various articles have appeared in the past few years giving the historical background ?and early development of carbide ?bits, this information will not be repeated. Table I lists the equipment used in the test work. The stopers weigh about 95 pounds and the jackhammers with airleg from 97 to 110pounds. The smaller rock drills are stated to deliver about 2,200 blows per minute at 1 to 30 rotation and to require 85 to 95 cubic feet of air at around 100 pounds pressure.

Jan 1, 1950