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By S. L. Weber, V. Castranova, D. E. Banks, J. K. H. Ma, Y. Rojanasakul, J. Y. C. Ma, M. Bhat

"The mechanism of bleomycin-induced pulmonary fibrosis is not ye: clear. Recent studies have shown that alveolar macrophages (AM) can be stimulated by bleomycin in vitro releasing inflammatory cytokines, suggesting that the interaction of bleomycin with AM is an important step in the drug-induced fibrotic process. Bleomycin is known to bind DNA and generate oxygen radicals through complexation with Fe2+ and oxygen. To provide,more insight into the cellular oxidative property of bleomycin, v.s have developed a fluoromicroscopic method using 2',7'-dichlorofluorescin diacetate (DCFHDA) as an oxidative fluorescence probe to study the deomycin-induced intracellular oxidation in rat AM and the inhibition of the oxida¬tion by taurine, a compound known to inhibit the bleomycin-induced fibrosis. Bleomycin at 5 to 20 ug/ml has a moderate stimulatory effect (1.87- to 2.66-fold) on the secretion of superoxide anion. A high concentration of bleomycin (20 ug/ml), however, inhibits cell response to zymosan-induced secretion of superoxide anion. At 4 ug/ml, bleomycin has no effect on cell membrane integrity or morphology but results in a significant increase in intracellular oxidation. This oxidative process is Fe2-,-dependent and is accompanied by an increase in intracellular calcium (35 nM). Both the intracellular oxidation and calcium rise induced by internalized bleomycin are inhibited by pretreatment of cells with varying concentrations of taurine (25, 125, and 187.5 uM). The inhibitory effect on intracellular oxidation .vas found to be 36, 57, and 60%, respectively. These results demonstrate a stimulation-inhibition relationship between bleomycin and taurine on re cellular oxidation at a subcytotoxic dose of bleomycin, suggesting that the oxidative effect of the intracellular bleomycin-Fe2 complex is important in the initiation of the fibrotic process. — Environ Health Perspect 102 (Suppl10):91-96 (1994) IntroductionThe pulmonary system is most susceptible to oxygen radical-induced diseases due to its constant exposure to the highest oxygen tension, and the potential encounters with oxidant gases such as ozone, nitrogen oxides, and toxic doses of dust particles. The lung is also a well-perfused organ and thereby vulnerable to the effect of circulating xenobiotics such as paraquat, and, bleomycin, which is known to cause pulmonary injuries (1). Alveolar macrophages (AM), which act as a means of defense by phagocytizing inhaled dust particles and microorganisms while increasing production of reactive oxidative species, have been shown to play an important role in mechanisms leading to oxidative lung injury and fibrosis (2-4)."

Dec 1, 1995

By W. L. Anderson

Standard tellurium analytical procedures were modified to obtain the greater sensitivity needed to support a survey of tellurium resources by the Bureau of Mines. Resulting volumetric and spectrophotometric methods for determining tellurium in all types of tellurium-containing materials are described. Sample decomposition and preliminary separations of interfering selenium, gold, and silver are the same in both procedures. The volumetric method is applicable to samples containing a minimum of 10 parts per million of tellurium, In this method the tellurium is reduced to elemental form, and the colloidal suspension is titrated with 0.01 normal iodine solution. The weight of sample for analysis, from 0.25 to 10 grams, should be selected so that the sample contains 0.1 to 5 milligrams of tellurium. To insure accuracy, duplicate samples should be run and the results averaged, particularly on samples of low tellurium content: The limit of determination is 0,001 percent tellurium, which is equivalent to 0.1 milligram of tellurium when using a 10-gram sample. The spectrophotometric method is particularly applicable to low-tenor materials containing from 0.5 to 50 parts per million of tellurium. Up to 10 gram samples are required for making accurate determinations in the low-concentration range. The sample used should contain between 5 and 100 micrograms of tellurium. The turbidity of a colloidal suspension of tellurium prepared from such a sample is determined in a spectrophotometer .t at a. wave-length of 440 millimicrons, and this value is compared with those of standard samples containing known amounts of tellurium.

Jan 1, 1963

By H. C. Fuller

Submerged combustion and inverse solubility methods were investigated as promising alternative means for crystallizing manganese sulfate from solutions produced by leaching manganese ores with either sulfuric acid or sulfur dioxide. Evaporation of water from typical manganese sulfate solutions by sub-merged combustion techniques enabled production of a slurry containing 32 to 39 pct MnSO4.H2O crystals suspended in a saturated solution of manganese sulfate. Such a slurry required further processing by thickening or filtration and drying to produce crystals of MnSO4.H2O. In a second approach, semicontinuous processing of manganese sulfate solu¬tions by thermal crystallization under pressure effected a recovery of 94.5 pct of the MnSO4.H2O as dry free-flowing crystals. Treatment of a solution containing about 100 grams manganese per liter at 189° C, produced a "barren" solution containing only 1.9 grams manganese per liter. Calculations made on comparable manganese sulfate solutions show that the heat requirement of the thermal crystallization method was about one-third to one-fourth that of the submerged combustion method.

Jan 1, 1966

By Scott W. Hazen, Richard F. Link, George S. Koch

The Mi Vida mine , Big Indian district , San Juan County , Utah , is in an ore deposit of uranium and vanadium minerals disseminated in certain sedimentary beds of the Triassic Chinle formation . Statistical analysis of assays of samples taken from the ore body affords an estimate of the grade of the ore body and provides a prediction about the direction of best mineralization beyond the sampled area . The basic data analyzed are assay results for uranium ( Uз Og ) , vanadium (V₂O ) , and lime (CaO ) from 225 channel samples cut at 79 sample points . Through the use of appropriate statistical methods , particularly regression analysis , the grade of ore may be estimated more precisely than by conventional means , and the most favorable direction to extend the mine may be predicted . Frequency distributions of assay residuals for uranium , vanadium , and lime are compared to frequency distributions of assays without regard to trend . Correlations among these variables are obtained and interpreted . The statistical methods employed illustrate certain techniques that may be used to analyze assay data from ore deposits in general .

Jan 1, 1964

By J. P. Powell

This report provides information on the techniques and results obtained on representative waterflooding projects in Cowley County, Kans. Records show that waterflooding was begun as early as 1935, but not until 1948 was the method expanded. The greater depths to the oil-producing formations in this area compared to those in eastern Kansas undoubtedly delayed the widespread use of secondary-recovery methods. This report presents a discussion of four waterflooding projects in Cowley County, Kans. The locations of these projects are shown in figure 1. The projects have been in operation from 1 to 7 years and have produced more than 1 million barrels of additional oil by injecting 11.5 million barrels of water. The projects are designed to take advantage of elevation and height of the separator tank to collect by gravity flow the produced brine at the respective treating or storage tanks. The closed-type water system is used on three of the projects and an open-type water conditioning system on the fourth. On one of the projects, which was drilled along a narrow shoestring formation, alternate well, were converted to input wells. However, most of the input wells for flooding converted producing wells.

Jan 1, 1958

By Daniel G. Di Canio

A computer based accident cost indicator model (ACIM) for estimating tangible costs of occupational injuries, illnesses, and fatalities in the U.S. mining industry is described. Studies performed to expand the scope of the ACIM to all mining sectors are presented. Validation of ACIM cost element estimation algorithms with actual costs of mining-related injuries and illnesses are presented. A study of the effect of a fatal accident on production in surface coal and metal/nonmetal mines is presented. The study is based on a sample of 15 fatalities in underground and surface mines. Evidence of significant long- term decline in postfatality production at 6 of 8 underground samples is presented. The average loss is shown to be 1.8% of annual mine production. A study of accident costs in U.S. mining from 1975 through 1981 using the ACIM is presented. The study shows that total annual costs increased from $180,000,000 in 1975 to $379,000,000 in 1981, a 15% annual increase after adjusting for inflation, with mining companies bearing 45% of the total and expected wage losses to mining families accounting for 42%. The study shows total costs of $12,400 per accident and $674,000 per fatal accident for 1981.

Jan 1, 1983

By Thomas C. Atchison, Joseph M. Pugliese

Six explosives were compared by measuring their strain- producing abilities in limestone . Peak strain , e , varied with scaled distance , R/Ro , according to the following equation : € = Kc (R /R 。)- ". The distance exponent , n , was a constant of the rock and did not depend upon explosive . The strain intercept , Ke , increased with increasing detonation pressure of the explosive . The strain intercept also depended upon the explosive- to - rock impedance ratio . For impedance ratios from 0.53 to 1.38 , the strain intercept was approximately proportional to the medium stress , Pn , as calculated from the explosive detonation pressure , P , and the explosive - torock impedence ratio , Z , by the simple elastic theory relation : P = 2P / ( 1 + Z ) . PD However , the data indicated that , at lower values of impedance ratio , the strain intercept is relatively larger than would be expected from the simple elastic theory . The results presented provide a simple method for predicting the relative effectiveness of different explosives in breaking limestone from the detonation pressures and characteristic impedances of the explosives .

Jan 1, 1964

By Charles J. Stehlik

This report deals with the changing behavior of mine roof bolt and roof rock as a result of repetitious production blasting . Observations were made in the upper shale production headings at the White Pine Copper Co. room and pillar mine , White Pine , Mich . Roof bolt compression pads and a stratascope were used in the investigations , which were carried out in three separate test sites in which nearly identical procedure produced comparative , repetitive , and anomalous observations . Results indicate roof bolt tension change and roof quality deterioration anomalies were coincident with blasting . The hypothesized cause of the anomalies is a seismic shock generated by the blasts .

Jan 1, 1964

By Charles M. Mason

The Bureau of Mines evaluated equipment and procedures for drop-weight testing of explosive liquids as prescribed by Test 4) a widely used method. It was demonstrated that partial ignitions, originally designated as negative results, should be designated positives; it was also shown that wear or erosion of the sample cups and the type of mount used for the apparatus had important effects on the results. Relative sensitivity as measured by Test 4 was found to vary slightly with temperature. The Bureau also designed a fixed 2-kg weight and associated electromagnetic release, which subsequently were incorporated as standard in a revision of Test 4. The original concept that the test involves only adiabatic compression was found to be an oversimplification; an alternate mechanism for the initiation process is proposed in which due consideration is given to the effects of cavitation and microjets.

Jan 1, 1966

By Robert L. Mentch

CADMIUM is one of the metals apparently destined to remain relatively scarce. The en tire supply of primary cadmium is recovered as a byproduct, concurrently with the treatment of ores of other metals. Development of the cadmium industry is attributed to metallurgical improvements in the zinc industry; output depends almost wholly upon zinc production. Cadmium is a metal of specialized uses where its superior performance has developed a strong, expanding demand. The supply, however, has been relatively unresponsive to price because of its byproduct nature. Cadmium's outstanding properties would assure it a manyfold greater market if more were available at lower prices.

Jan 1, 1958

By Robert C. Ellman

Stockpiles containing 2.3 million tons of lignite constructed in the period 1948-56 in conjunction with the construction of Garrison Dam on the Missouri River demonstrate successful stable long-term storage of lignite. Uniform and thorough compaction of each of the I-foot-thick layers by which the piles were constructed produced a bulk density of 70 Ib/cu ft. Air penetration into the stockpiles was restricted to a degree that prevents spontaneous heating or deterioration of the stored lignite, A continuing record of observations beginning with stockpiling operations in 1948 has been accumulated, This includes periodic fuel analysis, analysis of pile gases, and measurement of pile temperatures on the first large stock-pile, pile 5. This report describes the stockpiling method, the changes in heating value, pile gas composition, and pile temperature and summarizes observations from 1953 to 1964, Data accumulated attest to the stability of the stored lignite. The variation of the average heating value of periodic pile-depth samples is only 160 Btu/lb (11,990 to 11,830) on the moisture" and ash-free (maf) basis during almost 10 years of storage. Temperature levels of the pile interior are progressively decreasing. At pile surface, cyclic variations occur with the season. The only problem encountered with the large stockpiles is wind and water erosion of the pile surface. The partially successful control measures used are described.

Jan 1, 1967

By John D. Sullivan

The recovery of copper by leaching from relatively low grade ores containing both oxidized and sulphide minerals is rapidly gaining in commercial importance. There is an economic limit below which certain ores can not be treated by concentration methods, and material with values below this limit must be discarded, possibly to be treated later, or the copper must be extracted by wet processes. Heap leaching has been carried out by the Phelps Dodge Corporation, Copper Queen Branch, for several years, and to-day its plant is a large producing unit. The Ohio Copper Coy at Bingham, Utah; has been leaching in place since 1919. Many other leaching operations are also being; carried out in various parts of the United States and in foreign countries. The plant at Rio Tinto, Spain, may be considered the father of heap leaching.

Jan 1, 1931

By M. M. Wong, J. E. Klosterman

Scrap beryllium chips ( nominally 96 to 97 percent Be ) were electrore fined in a prototype cell with 408 lb of electrolyte composed of 52.4 mole - percent LiCl , 36.3 mole - percent KC1 , and 11.3 mole - percent BeCl2 . The cell temperature was 500 ° C. In a typical 10-3 /4 - hour deposition cycle , 0.415 pound of metal was produced ; the metal contained impurities in parts per million as follows : C , 700 ; 0 , 610 ; Al , 34 ; Ca , 32 ; Cu , 20 ; Fe , 25 ; Mg , 9 ; and Mn , 23 . Operation of the prototype cell for 2 years demonstrated that adapting the electrorefining process to an enlarged scale of operation presented few difficulties in mechanical functions , maintenance of optimum operating conditions , and control of product purity . After the spent anode feed was leached in a 5 - percent nitric acid solution and the fine - sized particles were removed , it was recycled in some tests . The metal produced was somewhat higher in impurities than metal from the fresh scrap chips .

Jan 1, 1964

By By Staff

"These proceedings consist of papers presented at a Bureau of Mines Technology Transfer Seminar on postdisaster survival and rescue research. Several seminars are held each year to bring the latest results of Bureau research to the attention of the mining industry as quickly as possible.INTRODUCTIONThe postdisaster research program is directed toward research and development of technology and equipment that increases the chances of a miner surviving or being rescued after an underground mine disaster. A disaster is an accident of major proportions, and it may result in the entrapment of miners whose normal egress from the mine is cut off. This often necessitates a rescue operation and a means of keeping the trapped miners alive while they await rescue. The Bureau is currently pursuing research to develop the technology that will enhance the ability of miners to survive such an occurrence. The research is divided into two basic problem areas, survival and rescue. Both areas are concerned with the inability of miners and rescue teams to cope with the postaisaster environment, such as toxic gases, unstable roof conditions, water flooding, and lack of oxygen. In addition, research is also conducted to find ways of locating and quickly reaching trapped miners. Most of the research conducted by the Bureau has been directed toward the postdisaster problems associated with coal mines. However, most of the research results are also applicable to noncoal mines as well.The papers presented in these proceedings address some of the recent research conducted by the Bureau of Mines that has been directed toward the postdisaster problems outlined above. The topics covered range from an overview of the technology developed for oxygen selfrescuers to training programs for mine rescue. Any questions or comments pertaining to this research are encouraged and appreciated. Open file report (OFR) references in the proceedings listed as available from NTIS may be obtained from the National Technical Information Service, Springfield, Va. 22161, and are also available for reference at Bureau of Mines facilities in Denver, Colo., Twin Cities, Minn., l3ruceton and Pittsburgh, Pa., and Spokane, Wash.; the Department of Energy facility in Morgantown, W. Va.; the National Mine Health and Safety Academy, Beckley, W. Va., and the National Library of Natural Resources, U.S. Department of the Interior, Washington, D.C."

Jan 1, 1982

By A. J. Kraemer, O. C. Blade

This report on the properties of commercial motor fuels sold in the United States is a continuation of a series of reports made in accordance with a cooperative agreement between the Cooperative Fuel Research (C.F.R.) Committee of the Cooperative Research Council (C.R.C. ) and the Bureau of Mines of the United States Department of the Interior . The first report contained data on motor gasolines sold during the winter of 1935-364 . Further reports on motor gasolines sold during the succeeding summers and winters to the summer of 1941 have been issued . No reports were made on motor gasolines sold during the winter of 1941-42 and during the summer of 1942 . The present report presents analytical data for 1,120 samples , representing the products of approximately 88 companies . As in previous surveys , these companies include both large and small suppliers . In addition, the Pacific coast is represented by data averaged by the Pacific Coast Technical Group before being submitted and are published exactly as they were received . Conforming to previous surveys , the data cover three groups of samplesregular - price , premium - price , and third - grade gasolines and each group has been averaged separately. The number of samples , items and brands comprising each group, exclusive of those of the Pacific coast, are as follows : Regular price , 641 samples , 250 items , and 64 brands ; premium price , 439 samples , 222 items , and 68 brands ; third - grade gasoline , 50 samples , 50 items and 19 brands .

Jun 1, 1943

By L. M. Adams

Experiments in reclaiming acidic surface-mined coal lands with raw fly ash from bituminous-coal-fired powerplants were conducted by the Bureau of Mines at two sites in northern West Virginia. Plots at both sites were treated with varying tonnages of fly ash from three area powerplants and were planted with a variety of grasses, legumes, trees, and shrubs. Eight grasses and seven legumes were investigated. Greatest promise for growth under harsh soil conditions was shown by Kentucky 31 fescue, rye and red top grasses, and birdsfoot trefoil, a legume. Survival of trees and shrubs was negligible. Addition of fly ash to the spoil increased the pH to a range tolerable to some types of plant growth, improved the texture of the soil, and increased the available water of the resulting mixture.

Jan 1, 1971

By D. Bienstock, J. H. Field, M. J. Lempel

A computer program is presented to perform the detailed and numerous calculations required for determining the interface temperatures and steady - state heat flow through a furnace wall composed of several refractories in layers . A method is developed that will allow the designer to determine the various thicknesses for each refractory layer to minimize either the total wall thickness or the cost of the wall per unit of area . A sample problem is presented and analyzed to illustrate the techniques involved .

Jan 1, 1964

By R. D. Currie

A study of the accident statistics in the coal mining industry convinces one that an organized effort must be put forth to prevent the vast destruction of human life in this industry . The fatality rate in Pennsylvania has not improved in the past several years and during 1928 it was higher than the average for the period 1916 to 1927 , inclusive . Although the accident rate for this State is less than that of the coal mines of the United States as a whole , nevertheless the rate is unduly high ; however , there are many companies which have exceptionally good records as regards both fatal and nonfatal accidents . A study of the methods used by some of these relatively good- record companies to reduce accidents in their mines shows that they exert an organized effort to prevent accidents , and that their safety organizations usually affect every employee in and about the mine from the highest official to the check boy . The chief executive must be actively and personally interested in accident prevention if real safety results are to be obtained ; when he shows this interest it is almost invariably reflected in the officials under him and throughout the organization . Safety organizations vary in form and are readily changed or adapted to the varying conditions found in the bituminous field . The companies whose organizations were studied in preparing this report are all getting good results , and it is their opinion that the safety organizations have been a big factor in obtaining these results . At their request the identity of some of the companies whose organizations were studied has not been divulged in this paper , but this does not affect the value of the information concerning their safety organizations .

Mar 1, 1931

By Fredrick L. Johnson

In 1984, at the request of the U.S. Forest Service, the U.5, Bureau of Mines began a study of the 94,370-acre Arc Dome study area (4-667) in order to appraise its mineral resources, The Bureau of Mines mapped and sampled mines, prospects, and mineralized sites in and near the area, The study area is located in the Toiyabe National Forest, about 54 mi north of Tonopah, Nye County, NV, It is estimated that over 500 claims have been staked in the study area since the mid-1800?s. In January 1986, there were 108 active mining claims completely inside and 59 on the boundary. Another 283 active claims were outside the study area but within 1 mi of the boundary, In addition to the large number of claims staked, exploration activity is also reflected by the almost 700 inactive workings that were found during field investigation.

Jan 1, 1989

After nine years of negotiations, the U.N. Conference on the Law of the Sea approved a Law of the Sea Treaty text in April. Israel, Turkey, the United States and Venezuela voted against the text and 17 other nations including Belgium, the Netherlands, Italy, the Soviet Union, the United Kingdom and West Germany abstained. These nations still have the option of joining the treaty when it is opened for signing in December. However, the Reagan Administration has stated that several provisions of the deep seabed mining portion of the text are unacceptable and it seems unlikely that the United States, at least, will change its position. ALUMINUM Reynolds Metals Co. has criticized an Oregon state plan to relax air pollution standards for aluminum plants. The company feels that relaxation of the rules does not go far enough. Reynolds officials say that they have spent about $31 million at their Troutdale plant for state-of-the-art pollution control equipment, and if they are required to make the pollution reductions called for in the 1986 rules, Reynolds would be forced to close the 40-year-old plant.

Jan 1, 1982