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By A. E. Gillis

"Some or all of the following benefits can be expected following application of automatic control to a grinding circuit:1. Maintenance of Optimum Mill Load Level2. Improved Uniformity of Grind3. Increased Productivity4. Decreased Power Costs per Unit of Product5, Reduced Ball Wear per Unit of Product6. Reduced Labour Costs per Unit of Product7. Reduced Operator SupervisionTo establish an indication of the benefits that could be expected through automation of the grinding circuit at East Malartic Mines Ltd. it was agreed that the Department of Mines and Milltronics Limited should jointly conduct a survey of the existing grinding circuit and operation.Aside from establishing feasibility, an important purpose of this survey was to determine costs of a suggested control system that East Malartic Mines Ltd. management might be in a position to assess the economics of the proposal and justification of the investment.The survey involved the taking of sound recordings of rod and ball mills during manual operations, locating circuit bottlenecks, establishing time constants and determining the number and location of sensors for good automatic control."

Jan 1, 1966

By Robert S. G. Chapman, Kieran M. J. Downes

The Sulphide-Preview Lakes area is located 45 km northeast of La Ronge in northern Saskatchewan. It lies within the southern portion of the Proterozoic La Ronge Volcanic-Sedimentary Belt. Two styles of gold mineralization are present in the Sulphide Lake area , stratabound gold mineralization is intimately associated with a pyrite-pyrrhotite-arsenopyrite-bearing graphitic argillite unit within a sequence of intermediate to felsic volcaniclastics. Past operators established three mineralized zones along this horizon with combined reserves for two of the zones, of about 175,000 tons at 0.22 oz/ton Au. In the Preview Lake area , gold mineralization occurs in variably sheared gabbro/quartz diorite sills within a mixed sedimentary-felsic volcaniclastic sequence. Gold occurs with arsenopyrite, pyrite and minor chalcopyrite associated with quartz veins and stringers. A sulphidebearing graphitic argillite unit occurs in close proximity to the mineralized shears. Past operators delineated seven mineralized shear zones, two of which were drilltested. Average gold grades reported are in the 0.1 to 0.2 oz/ton range with erratic values up to 5.0 oz/ton.

Jan 1, 1986

By . A. C. Atenas

Control of arsenic in the Potrerillos' Refinery electrolyte has been obtained by withdrawing a bleed stream of circulating electrolyte and ensuring the ratio of [O]/[As] in the cast anodes is maintained between 0.9 and 1.0. In order to achieve this control the anode oxygen must be adjusted, depending on the arsenic level in the cast anodes. It has been necessary to modify the time of the reduction step in the anode furnace refining process. Control of this ratio has permitted electro refining of anodes with high levels of arsenic, up to 3000 ppm, while minimizing the volume of electrolyte that must be removed for impurity control so as not to affect the copper concentration in the electrolyte. However this control strategy is not useful when the arsenic concentration in the cast anode is too high, because it is limited by the maximum oxygen concentration allowable for a good quality anodic. Costs have been reduced in anode furnace refining because it is no longer necessary to use alkaline flux injection to remove the arsenic in cast anodes.

Jan 1, 2007

By N. Schmitt, E. Blond, F. Hild

Working linings of steel ladles progressively damage during the steel manufacturing process due to both severe thermomechanical and chemical stresses. In the framework of the coupling scheme proposed by Blond et al. (1), this study examines the effects of the thermomechanical loading on the onset of microcracking by considering that the complex microstructure of the slag-impregnated brick is fixed during the steelmaking process. The behaviour of the refractory is identified by using thermoelastic-(asymmetric)viscoplastic constitutive equations. Numerical simulations of a simplified geometry of the lining subjected to cyclic thermal loadings at the inner side are shown. Two cases are analysed, namely, i) the material is a homogeneous continuum with a thermoelastic-(asymmetric)viscoplastic behaviour, ii) the material is porous and saturated by liquid slag, and the skeleton has the previous non-linear behaviour. The stress and strain fields are shown, and for the porous medium the interstitial pressure of slag as well. Comparisons between these assumptions are made to assess the role of slag on the degradation of the working lining.

Jan 1, 2004

By Douglas E. Wolfe, Jogender Singh, Robert Miller, Dong-Ming Zhu, Jeff Eldridge

This paper discusses microstructural changes produced by two novel approaches using electron beam physical vapor deposition (EB-PVD) in which periodic strain fields/microporosity was incorporated within the large columnar grains of Zr02- 8wt.%Y2O3 (8YSZ). The traditional columnar microstructure of partially stabilized zirconia has been slightly modified to produce a lower thermal conductive thermal barrier coating (TBC) by periodically interrupting the condensing vapor resulting in microstructural modifications with diffuse or sharp interfaces and morphological changes on the sub-micron scale without changing the composition of the TBC. These microstructural modifications resulted in a 20-30% reduction in the thermal conductivity, 28-56% increase in hemispherical reflectance, improved oxidation cyclic life (over 100%), and better strain tolerance as compared to standard ZrO2-8wt.%Y2O3 deposited on platinum-nickel-aluminide and CoNiCrA1Y bond-coated MAR-M-247 test samples. The TBC with tailored microstructures were examined by various techniques including scanning electron microscopy (SEM), x-ray diffraction (XRD), steady-state laser heat flux technique, and hemispherical reflectance.

Jan 1, 2004

By G. J. Hawkes

"We all know that every man who works for us should have a thorough knowledge and understanding of his responsibilities. But how about ourselves? Du we have a thorough knowledge and understanding of our own responsibilities as Mill Superintendents?I once had an occasion to say to a Manager that I did not know something was my responsibility and he replied with suitable emphasis ""Everything inside those four walls is your responsibility"". That makes the extent of our responsibilities clear but does not give us a check list to keep an eye on as we do our job from day to day.What are our responsibilities? I suggest they are the following:1. Developing and maintaining efficient operating and maintenance crews.2. Milling the required tonnage.3. Recovering the economical maximum amount of gold.4. Keeping costs at the economical minimum.5. Seeing that the figures are reasonably accurate for tonnages, assays, production, losses, and costs.6. Preventing accidents.7. Preventing fires.8. Maintaining the equipment and building and keeping them clean and tidy.9. Enforcing company rules and regulations."

Jan 1, 1965

By K. D. Watson

"THE Mindamar zinc-lead-copper mine, owned by Mindamar Metals Corporation Limited, is at Stirling in Richmond County, near the south-eastern shore of Cape Breton Island, Nova Scotia (Figure I). It is connected by several roads with the Canadian National railway at Sydney and St. Peters.The deposit is said to have been discovered around 1895 as an outcrop in the bed of Copper brook, but the details are obscure. Not until 1925, when it was optioned by American Cyanamid Company, was it developed underground. Between 1927 and 1938, the 1-nine was operated intermittently by The British Metal Corporation (Canada) Limited, and yielded approximately 200,000 tons of ore averaging about IO per cent zinc, 2 per cent lead, I per cent copper, and small quantities of silver and gold. In December 1950, Dome Exploration (Canada) Limited made an agreement with Mindamar Metaî Corporation Limited, which was exploring the old mine, to assume management and prepare the property for production. Production started in April 1952 with a new mill and a new four-compartment shaft, and between that time and the end of 1954 it has totalled 545,347 tons of ore averaging 5·89 per cent zinc, 1·35 per cent lead, 0·66 per cent copper, 0·032 oz. gold, and 2 151 oz. silver.The Mindamar orebodies are irregular lenses and large veins lying within a wide, almost vertical shear zone of remarkable persistency. The shear zone consists mainly of well-foliated sericite schist derived from siliceous siltstone, and it contains a vast amount of dolomite and magne-site of hydrothermal origin. Most of the ore is extremely fine-grained and some of the high-grade material has a conspicuous thinly layered structure. The metallic minerals, in order of decreasing abundance, are pyrite, sphalerite, chalcopyrite, galena, and tennantite; the gangue minerals, in the same order, are dolomite and magnesite, quartz, sericite, talc, chlorite, barite, albite, and alunite.The geological setting of the deposit is shown in Figure 2. Except along streams and lake shores, almost all of the bedrock is concealed by glacial drift. The group of rocks in which the deposit occurs consists principally of greywacke, siltstone, tuff, brecoia, and Javas, and has been correlated lithologically with the Bourinot group of Middle Cambrian age. A short distance west of the mine, these rocks are in contact along the Stirling fault with conglomerate, arkosic sandstone, and quartzite belonging to the Middle River group of Silurian or Devonian (?) age, which elsewhere in the area overlies the Bourinot group unconformably. The large bodies of granitic rocks in the region, and the large lenticular masses of diorite and quartz diorite associated with them, have been assigned by Weeks (5, pp. 68-69) to the Devonian."

Jan 1, 1949

By J. Arzúa, L. R. Alejano, P. Rodríguez

"After six years of successful excavation with a support pattern, some roof failures have happened in a room-and-pillar underground mine excavated in a stratified rock mass. In this paper the authors give explanation to the failure mechanisms and redesign the support in order to solve the recent problems of roof collapse.The mine magnesite bed is approximately 14 m thick, and runs in the E-W direction with an average dip of 18º. Due to mine constraints and the inexpensiveness of the ore, the excavation is performed in the mineral itself, avoiding the need for mining dumps and waste excavation. Rooms and drifts are oriented in the mineral bed to form an angle of 19º to the direction of the strata, reducing the roadway gradients to less than 10%. Rooms are 11 m wide and pillars are 7 m wide. They are designed to leave a 1 meter thick magnesite bed in the roof of the rooms to act as a supporting beam. More often than not there is a layer of very poor quality marly shale up to 1 m thick resting on this magnesite beam. Overlying the poor quality marly shale there is a better quality, self-supporting sandy shale.First, a characterization of the involved rock masses (magnesite, marly shale and sandy shale) is performed, collecting the geotechnical data from previous studies and performing new in situ geotechnical surveys to check the soundness of the previous data. A distinction is made between different quality zones inside the mine by means of the RMR classification, associated to the occurrence of faults.Back-analysis of some of the failed rooms and data from exploration boreholes were used to determine the failure mechanisms (associated to Voussoir type failure or occurrence of sub-horizontal joints crossing the magnesite beam). Based on an understanding of these mechanisms, the method used to design the support and to analyse the stability of the different possible thicknesses of the magnesite beams of the rooms and drifts of the mine were improved.Numerical models of the most relevant conditions found in the mine were performed in order to better understand the behaviour of the roofs and to simulate the supporting solution obtained in the previous analyses.The most relevant conclusions with regard to the main elements causing the instability of the roof include the appearance of sub-horizontal discontinuities crossing the magnesite bed, which causes total instability of the roof and usually leads to collapse; excessive thinness of the magnesite beam in the problematic rooms; and the relaxation of the deepest (around 270 m in depth) zone of the mine because of existing faults."

Jan 1, 2015

By A. K. Debnath

Coal is the mainstay of Indian energy supplies. The many-fold increase in demand for coal puts a huge pressure on augmenting production, primarily from opencast mines. The increase in production necessitates heavy blasting in overburden and coal benches of opencast mines, which poses numerous challenges in carrying out blasting operations techno-economically. Presently, the consumption of industrial explosives and accessories in Coal India Limited (CIL) has touched a whopping figure of $350 million USD per annum and CIL will be spending approximately $1 billion USD between 2012?2013 to 2014?2015 for procuring explosives and accessories. This paper discusses some of key challenges faced in various mines of CIL during blasting, where blast instrumentation at the mine level will prove to a harbinger for practicing blasting engineers. Presently, the problem of scattering in surface detonators and down-the-hole detonators affects the blast performance significantly by increased blast induced ground vibration and reduced fragmentation. The paper discusses a case study carried out at Umrer opencast project of CIL to investigate the effect of scattering by using blast simulation techniques (i.e., JKSimblast) and observing the actual blast results with the help of a high-speed camera and multi-channel high frequency data acquisition systems. The fragmentation assessment was carried out by adopting Digital Image Analysis techniques and using the granularity software viz. Wipfrag. The blast instrumentation in the case study mine resulted in improvement in fragmentation of 12.76% and a direct savings in explosives cost of 28%. Geophysical techniques such as the seismic survey method have been used at Umrer Project, CIL to characterize the rock mass using the Multi Channel Analysis of Surface Waves system for selecting the explosives technoeconomically. The minimum deck thickness for mines of CIL using drill cuttings as decking materials should be 10 D, where D is the drill diameter. The estimation of blast performance on the basis of prescribed Powder Factor (i.e., kg of explosives per m3 of rock) is technically unscientific as the criterion of a good blast depends on many factors (i.e., good heave, loose muck, muck profile angle, ease of digging, uniform fragmentation). The present paper proposes a new methodology for techno-economic evaluation of blast performance. The new methodology involves four significant factors viz. specific energy consumed by the loading equipment, charge factor, productive yield and diggability index for assessing blast performance. The use of user-friendly, accurate, reliable, rugged and handy instruments in blasting will significantly improve mine productivity, equipment efficiency and economics. The improvement in blast performance, even by 1%, will provide a significant savings of $3.5 million USD per annum to CIL. It may be concluded with high degree of confidence that blast instrumentation at the mine level will influence the mine productivity and economics.

Aug 1, 2013

By Gary Walters, Matthew White, Thomas W. Gonzales

The copper smelting industry has transitioned into the 21st century compliant with environmental regulations, new smelter installations and brown field expansions. The industry faces new challenges as copper in concentrate grades have decreased while contained impurities have increased. A new benchmarking survey was undertaken to update the last survey of 2016 for operating copper smelters in the world. The information collected was separated based on primary smelting technology rather than by geographical location and supplemented from published literature. Each smelting technology’s unique use of specialized process equipment, concentrate smelting capacity, and impurity flexibility are discussed INTRODUCTION The 20th century was a remarkable time for the growth of copper smelting. Electric, blast and reverberator furnaces dominated the smelting technology well past WWII. In the 1970s, SO2 regulations and high energy cost drove the development of new primary smelting technology. Technological advancements decreased energy consumption and enriched sulfur dioxide concentrations of the process off-gas to levels where sulfur capture in sulfuric acid plants was economically viable. The new smelting technologies began to replace reverberatory and electric furnaces starting in the late 1940s. A new paradigm in copper smelting was established and the enabler was then Outkumpu’s® flash smelting technology from the 1940s through to today. Now, Outotec had become the dominant primary smelting technology with over 44 copper flash smelting furnace installations world-wide. Figure 1 shows the historical installation statistics of primary smelting technologies over the last 70 years (ICSG 2018). The dominance and acceptance of the Outotec® smelting technology from the 1940s to current can be seen. Isasmelt® technology for copper was introduced in the 1970s and did not see advancement in new installations until the 1990s through today. Isasmelt® has 12 world-wide copper furnace installations to date. Mitsubishi® also introduced continuous smelting and converting technology in the 1970s, but had no new installations until the 1990s with a total of 5 copper smelters. Outotec Ausmelt® smelting technology had 3 installations in the 1990s and totals 10 furnaces. Most recently the Chinese technology of Bottom Blown and Submerged Lance Smelting began commercial operations in 2005 for total installations of 11, mostly in China. Other technologies, such as, El Teniente, Noranda, Inco, and Vanyukov furnaces have contributed to the overall global smelting capacity, but have not penetrated the smelting industry to challenge the existing dominant smelting technologies. The technology distribution in Figure 1 also shows flash smelting technology for sulfide concentrate domination untill 2000, bottom blow technology has become the preference in China. Currently, China is the only country building new smelting capacity. Isasmelt® technology also seen a large increase in installations in the current decade.

Jan 1, 2019

By T. Sugawara, H. Sekimoto

Electrorefining of low-grade copper alloys containing various amounts of nickel, lead, antimony, bismuth, arsenic, selenium, silver, and gold in sulfamic acid media was demonstrated. The copper concentration of the alloys used as an anode was 70–90 wt%. The electrolyte contained 100 g L-1 of free sulfamic acid and 40 g L-1 of cupric ion. Galvanostatic electrolysis was conducted at 200–300 A m-2 in the electrolyte using a low-grade copper alloy anode and a stainless steel cathode at 25C. The terminal voltage was approximately 0.8 V at the start of the electrolysis, although it increased periodically to approximately 2.0 V and then shortly returned to its initial value. Nickel, lead, and arsenic from the anode dissolved in the electrolyte and were removed. Antimony, bismuth, selenium, and silver were removed as solids. Consequently, a dense copper cathode was obtained, and the concentration of copper was evaluated by inductively coupled plasma – optical emission spectrometry to be 99.82–99.99 wt%. INTRODUCTION Electrorefining of copper is conventionally carried out in a sulfuric acid electrolyte using crude copper assaying at 99.5 wt% Cu as the anode (Biswas & Davenport, 1994). Elements more noble than copper do not react anodically, and consequently, they are distributed in anode slimes. Elements less noble than copper dissolve from the anode. Nickel and arsenic are stabilized as aqueous species. Lead, antimony, and bismuth react with water, sulfuric acid, or arsenic acid to form barely soluble compounds; thus, they are distributed in anode slimes. An emerging issue in the electrolytic refining of copper is an increase of impurities in crude copper used as the anode (Moats et al., 2013). This is due to an increase in the content of impurities in copper concentrates as well as an increase in the types of secondary copper feedstocks (e.g., E-Scraps, automotive shredder residues, and smelting residues) treated in the copper pyrometallurgical process. An extreme case is a copper smelter that does not use copper concentrates as feedstocks. In such a process, copper-bearing feedstocks are smelted in a top submerged lance furnace to prepare low-grade copper alloys assaying at 80– 90 wt% Cu (Sekimoto et al., 2013). Such low-grade copper is not acceptable as an anode in the conventional copper electrolytic refining process because it is easily passivated during electrolysis. Consequently, electrolytic copper is produced by leaching the atomized low-grade copper in a sulfuric acid solution with oxygen, followed by electrowinning. However, electrowinning should be avoided whenever possible because the electrical energy consumed in electrowinning is 5–10 times higher than that consumed in electrorefining. Therefore, the development of technologies for electrorefining of low-grade copper alloys is desirabl.

Jan 1, 2019

By Antonio Laguna

During the past few years, synthetic efforts have been addressed to the synthesis of polymeric materials with optical or semiconducting properties or even with capabilities to act as sensors for volatile organic compounds (1). The most recent studies have been concerned with the synthesis of heterometallic systems with short metal-metal interactions and the determination of their optical properties. These complexes are undoubtly interesting from a theoretical viewpoint and include an emerging class of luminescent materials, in which the observed luminescence results mainly from the interactions among the different metal centers, as well as the environments of these atoms. The understanding of the photophysics and photochemistry of these products could permit the design of complexes with appropriate metals and ligands chosen for individual applications. Following a synthetic strategy consisting on reactions between acid heterometal complexes and basic gold precursors we have succeded in synthesizing supramolecular assemblies formed via acid-base stacking, which display tunable luminescence or selective and reversible sensitivity to Vapour Organic Compounds (VOC?s) (2-5). In this sense, in accord with previous Mössbauer studies carried out in the gold precursor complex [AuR2]- (R = C6F5), the basic properties of this and related materials have been employed as building blocks of supramolecular assemblies in their reactions with complexes in wich the metallic centers act as lewis acids as, for instance, Tl(I) or Ag(I) (6). For instance, in the case of silver, by reacting equimolecular quantities of [NBu4][Au(C6F5)2] with AgClO4, in acetone, a solid of stoichiometry [Au2Ag2(C6F5)4(OCMe2)2]n is obtained. The polymeric nature of this material in solid state is confirmed through X-ray analyses (figure 1). It consists of polymeric chains formed by repetition of Au2Ag2 moieties linked through short gold-gold interactions. Nevertheless, in solution, the nature of this polymeric materials was still a matter of controversy and, in this case, the optical properties have been shown as useful tools in order to obtain information. Thus, while dilute acetone solutions of this complex give a emission coming from pentafluorphenyl localized ??* excited states, in accord with the presence of isolated tetranuclear Au2Ag2 units, when the measurements are done at different and higher concentrations, a band that does not obey the Lambert-Beer law appears. This deviation is consistent with molecular aggregation in solution of these units through gold-gold interactions, and a clear correlation between the emssion wavelength and the structure in the solid state and in solution is shown (figure 2). DFT calculations accord with the observed experimental behaviour and show the nature of the orbitals involved in each transition.

Oct 1, 2003

By G. Vibert Douglas

THE prospecter and geologist in the field, in the search for gold, are very often faced with a real difficulty. The: mineralized rock _frequently contains gold which is so finely divided or associated with sulphides that it is not recognizable in the gold pan. In recent years, the practice has been to take samples, send them to an assay office, and sit down and wait for results. This paper describes a method of solving the difficulty of proving the presence of this fine gold. The investigation is still in an experimental stage; but certain results have been obtained which would seem to justify publication. We do not consider that the method outlined is quantitative, but we believe that qualitative results are assured. The procedure has the great merit of simplicity. A sample of approximately two pounds of the mineralized rock should be taken and powdered as fine as is practicable. This powder is theo panned and the heavy minerals concentrated. Approximately two grams of these concentrates are taken for the test (one gram can be roughly gauged in the field by heaping up the powder on a Canadian twenty-five cent piece). The material is placed in a test-tube and 6 c.c. of a 10 per cent solution of iodine in alcohol are added (one-third of a test-tube full is approximately equal to 6 c.c.). Heat gently for about ten minutes over a spirit lamp, but without actual boiling. Allow to stand undisturbed until the sediment has settled to the bottom. Remove the clear iodine solution with an eye dropper. Allow it to fall, drop after drop, on a warmed pyrex watch-glass (the drops should be of equal size), taking care that the successive drops fall in the same place and that each drop evaporates before the next drop falls. Heat is applied to the lower side of the watch-glass by means of a spirit lamp. If gold is present in amounts of $2.00 or more per ton, a gold mirror will be formed on the watch-glass. This process of dropping and evaporating should be continued until no clear solution remains. If no mirror has appeared when all the solution has been used, another 6 c.c. of the iodine solution should be added to the powder and the process repeated. The absence of a mirror after the double treatment denotes an amount of gold less than two dollars per ton at the present price, or that the ore contains no gold. The mirror obtained must be washed with nitric acid ( 1: 1) to remove any copper, silver, lead, zinc, and iron. The yellow mirror remaining is pure gold.

Jan 1, 1937

By Martin G. Wafforn, George J. Greer

"In early 2014, Pan American Silver Corp. commenced a project to construct a second shaft at its La Colorada underground mine located in Zacatecas State in Mexico. This was the first new shaft development project undertaken by Pan American Silver in the history of the company. The existing mine workings permitted the use of a raise bore for the excavation of the shaft opening, utilizing directional drilling in poor ground conditions to advance the pilot hole. This was an interesting project with many challenges and successes, and numerous lessons learned. The project was successfully completed in 2016, with the shaft operating at full mine production capacity within weeks. INTRODUCTION The La Colorada Mine has a long history dating from at least the 1920’s. The mine is located in the northern portion of Zacatecas State in Mexico in the Chalchihuites area, an approximate two hour drive south from the city of Durango. Pan American Silver acquired the La Colorada mining concessions in 1998, with mine production at that time consisting of only a few hundred tonnes per day. Over the course of the following 15 years, with the addition of an oxide processing plant and some expansions to the sulphide processing plant and site infrastructure, production was eventually increased to a maximum of 1,250 tonnes per day, all of it generated from conventional cut-and-fill stopes in the underground mine. An existing shaft was used to hoist the ore to surface, and over the years Pan American Silver had deepened the shaft and had changed out some of the hoisting plant. However, there were historic workings in close proximity to the shaft that made it unsuitable for personnel transport, and shaft maintenance was becoming difficult. The shaft was increasingly considered as a risk to the long term production continuity, and also to further deepening of the mine. In addition, expanding the capacity of this old shaft was not possible. Drilling of the La Colorada mineralization at depth commenced in 2010, with very good exploration success. As a result, by the end of 2013, the mine reserves had grown to a total of 6.5 million tonnes of high grade ore (388 g/t Ag, 0.36 g/t Au, 2.4 % Zn, and 1.3% Pb). Furthermore there were more (and higher grade) sulphide reserves than oxide reserves at depth. Following the completion of an internal study in 2013 with assistance from one of the international shaft contractors, a decision was made to increase the production from the mine with the construction of a new shaft and a new sulphide processing plant, a project with a calculated payback of 2.2 years."

Jan 1, 2019

By Peter J. Barnard

Mitochondria play a key role in the regulation of apoptosis (cell death) and in diseases characterised by abnormal apoptotic responses such as cancer. Mitochondrial membrane permeabilisation (MMP), regulated by the mitochondrial permeability transition pore complex, is widely accepted as being central to the process of cell death. As a result there has been considerable recent interest in targeting mitochondrial cell death pathways in the development of new chemotherapeutic agents.(1) There is potential to overcome the two overriding problems in cancer chemotherapy?the common occurrence of drug-resistant tumour cells and the lack of selectivity of cancer drugs in differentiating between tumour cells and normal tissues. Significantly, carcinoma cells have an elevated mitochondrial membrane potential relative to normal cells and lipophilic cations are concentrated within mitochondria in response to mitochondrial membrane potentials. There is potential for the selective targeting to tumour cells with compounds having optimal lipophilic-hydrophilic character. Research stemming from the early 1980?s points to two distinct classes of Au(I) phosphine antitumour agents where an antimitochondrial mode of action has been implicated: (i) neutral linear two-coordinate Au(I) complexes such as triethylphosphinegold(I) chloride and the tetraacetylthioglucose gold(I) phosphine complex, Auranofin; (ii) cationic tetrahedral bis-chelated Au(I) phosphine complexes related to [Au(dppe)2]+.(2) Recently it has been reported that Auranofin, at submicromolar concentrations, induces MMP observed as mitochondrial swelling and dissipation of membrane potential.(3, 4) Both events are completely inhibited by cyclosporin-A, the specific inhibitor of MMP. The permeability changes were shown to occur at concentrations associated with the selective inhibition of mitochondrial thioredoxin reductase.(3) Auranofin is a potent and specific inhibitor of this enzyme due to Au(I) binding to the active-site selenol group.(5) The redox state of mitochondrial thiols may be critical in the control of MMP.(3) In general, swelling is stimulated by thiol blocking or oxidising agents and is prevented by thiol reducing agents.(1) Mitochondrial thioredoxin reductase may play an import role in the redox control of the permeability of mitochondrial membranes.(3) Our interest is in investigating the antitumour potential of Au(I) phosphine compounds using a number of different approaches. In recent work we have evaluated a series of hydrophilic analogs of [Au(dppe)2]+ containing pyridylphosphine ligands which have demonstrated greater tumour selectivity than the parent compound. To investigate the possible antimitochondrial mode of action we are studying the effect of [Au(dppe)2]+ and related compounds on isolated rat liver mitochondria. To assess whether the lipophiliccationic nature of the compounds determines the antitumour activity, we have synthesized a series of novel Au(I) complexes based on heterocyclic carbene rather than phosphine ligands. The similar chemistry and structural features of the two classes of complexes allow us to assess whether the phosphine ligands are essential for the antitumour properties.

Oct 1, 2003

By P. Farsangi, A. Hara

"Kidd Creek Mines places approximately 10 000 tonnes of consolidated rockfill on a daily basis. Consolidated rockfill is comprised of sized aggregate mixed with different ratio and amounts of binders. Consolidated rockfill, with closely controlled specification, is employed for subsequent pillar recovery and improved passive active/ ground support. With the same amount of cementing agents consolidated rockfill mass yields a higher, compressive strength, modulus of elasticity, cohesion, and angle of friction compared to a typical cemented hydraulic fill mass.The consolidated rockfill at Kidd Creek Mines is designed to sustain not only the gravitational loading of the overlaying fill material, but also to some extent the dynamic loading applied during blasting of the adjacent stopes and/or pillars.The quality control of materials used in Kidd Creek's rockfill system could be effected in three stages of handling: (1) at the surface backfill plant; (2) during transportation; and (3) placement of the fill.The emphasis in this paper is placed on individual stope backfill design and quality control measures at Kidd Creek Mines to place fill in large-scale open stopes which eventually could be exposed on all four walls during pillar recoveries."

Jan 1, 1993

By Brian W. Mackenzie

"This paper briefly outlines the characteristics which should be considered in assessing the economics of mineral exploration, and illustrates such an assessment by using data from the Canadian base metal sector. Implications for the sector are found to include the following:(1) base metal exploration has the potential to create a substantial amount of new wealth;(2) investment incentive for exploration under current conditions is not unattractive over-all;(3) because of existing taxation policies, there is much more incentive for large companies to explore than for smaller enterprises;(4) succesful exploration is sensitive to the size, financial resources and organizational structure of the exploration entity;(5) the general level of recent exploration expenditures should be adequate to maintain the current rate of production and perhaps to support very modest growth; and(6) there is an important opportunity for growth in the sector.The findings of the study suggest that government policies should be made more flexible, in order to take into account the risks associated with exploration and with price fluctuations in the base metal sector. Recommendations are also made concerning improvements in provincial regulations for disclosure of exploration information."

Jan 1, 1981

By S. I. Vobnout, J. Wm. White, J. P. Olson

"Mine management now recognizes the value of computer-based truck-shovel dispatching in open pit mines. The key tangible benefits are substantial productivity increases with a given fleet of equipment or, alternately, significant reductions in equipment required to meet production quotas. In this paper, the authors review the literature, report on efficient, optimal algorithms for haul truck dispatching in real-time, and briefly discuss methods used by various mines to evaluate productivity improvements over manual methods. Actual results obtained at thirteen mining operations around the world are also presented.IntroductionModular Mining Systems manufactures, installs, and supports its computer-based DISPATCH system at mines worldwide. DISPATCH is a large scale, computer-based mine management system which controls the dispatching of all haul trucks in any open pit mine (Fig. 1). When increased production is important, DISPATCH gets the needed production increase with fewer new or recommissioned trucks. DISPATCH also helps operations meet its blending objectives while minimizing rehandle and maintaining production. Furthermore, DISPATCH includes a powerful, eventdriven simulation subsystem. With the simulator mine management can pose ""what if' situations and see the predicted effect on production"

Jan 1, 1993

By J. G. Henning, T. R. Yu, J. E. Croxall

"Test work was carried out to investigate the thermal response of loose and solid rock under varying environmental conditions. The primary interest was to develop a technique that could be used to increase the thermal variation between loose and solid rock for better detectability of loose rock underground with a thermal imaging infrared scanner.A variety of thermal enhancement methods were evaluated both in the laboratory and in the mine environment. Air temperature variation created by the exhaust from diesel driven, mobile mining machinery was studied in detail. When sufficient hot exhaust was supplied to the air, unsteady thermal conditions became more pronounced on the rock surf ace. This allowed a greater percentage of loose rock to be detected by a high-resolution infrared scanner within minutes.The degree of thermal enhancement of loose rock was found to be dependent directly on the thermal conductivity of rock, looseness, air temperature change, and inversely on the size of loose, airflow rate and distance downwind from the heat source. It was also found that an air temperature rise of at least r c, or rock temperature differential of1°C was necessary for minimal thermal enhancement required f or infrared detection."

Jan 1, 1990

By N. Haghdadi, D. M. Maijer, A. B. Phillion

B206 is a recently-developed high-strength Al-Cu casting alloy with reduced Ti and Fe, as compared to the well-known AA 206 alloy, for improved hot tearing resistance. In the current study, the solidification kinetics of this alloy as a function of cooling rate from 1 to 15 K/min were studied using differential scanning calorimetry (DSC) and microscopy. Specifically, the evolution in fraction solid, grain size, and secondary dendrite arm spacing have been characterized. The DSC results show the occurrence of three peaks during cooling from the liquid state, which are related to the formation of primary aluminum, a pre-eutectic intermetallic, and the eutectic phases. Thermal analysis also indicates that while the liquidus temperature is not sensitive to the cooling rate, the temperatures at which the pre-eutectic and eutectic phases form are strongly coupled to the rate of heat extraction. A decrease in the latter temperatures was observed when the rate of solidification was increased, leading to a lengthening of the freezing range of the primary phase. The results will be useful for improving B206 casting processes, specifically through modification of mould cooling conditions.

Jan 1, 2014