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By Y. H. Cheng, D. M. Lewis, V. Castranova, M. W. Barger, J. K. H. Ma, J. Y. C. Ma, W. F. Xin

Bis-basic ethers off fluorene and fluoren-9-substituted derivatives such as tilorone have been reported to inhibit silica-induced fibrosis in rats. The potential antifibrotic potency of 2,7-bis (diethylamino) ethixy fluorine fluorenone (F-9-H.H), fluorenoxime (F-9-one), and fluorenol (F-9-ol) was F-9-axime > F-9-one ~ F-9-H,H > F-9-ol. Since the release of reactive oxygen species and growth factors from alveolar macrophages (AM) in response to silica exposure has been linked to the development of pulmonary fibrosis, the present study was carried out to determine the inhibitory effects of these compounds on rat AM activity in vitro. The following parameters were monitored: (1) cellular viability; (2) zymosan-induced respiratory burst activity (superoxide and hydrogen peroxide release, chemiluminescence, and oxygen consumption) of AM; (3) drug binding to AM; and (4) lipopolysaccharide (LPS)-stimulated interleukin- I (IL-1) release from AM. The bis-basic ethers, at 40 did not affect cell viability when incubated with AM for 30 min, but significantly inhibited zymosan-induced macrophage respiratory burst activity. The inhibitory effect of these agents was F-9-oxime > F-9-one ~F-9-H,H > F-9-ol. Binding of these drugs to AM was time and dose dependent, and exhibited the following binding affinity: F-9-oxime > F-9-one > F-9-H,H > F-9-ol. F-9- oxime was shown to inhibit LPS-stimulated IL-I release by AM in a dose-dependent manner. This inhibition of IL-1 release by AM cannot be explained as a decrease in viability. In addition, these drugs were also shown to impair human fibroblast proliferation in response to serum stimuli without impairing cell viability. These results indicate a positive correlation between drug binding to AM or other cell types and their inhibitory effects on cellular activities including oxygen consumption, superoxide release, hydrogen peroxide secretion, chemiluminescence, IL-I release, and proliferation. The ability of-these bis-basic ethers to modify AM and fibroblast functions in vitro suggests that further investigation of their reported antifibrotic potency in vivo is warranted.

Dec 1, 1996

Demonstrate the technical feasibility of using nontraditional, low-rank, coal-based fuels and new coal-based technologies for mineral and metallurgical applications. Approach A cooperative research effort was initiated between the Bureau of Mines, U.S. Department of Energy and the minerals industry to extend the application of the fixed-bed gasification process to low-rank Western coals. The research effort enabled cooperators to gain operating experience in the use of hot, raw producer gas for iron ore pellet induration and other high-temperature mineral processes. Researchers were able to gather data regarding the fundamental engineering aspects of the fixed-bed process and gas cleanup for a wide range of solid fuel properties. Applying Fixed-Bed Gasification As a prerequisite to gathering the data needed for the study, the Bureau of Mines designed and installed, at one of its laboratories, a 6.5-ft-diam. single stage, fixed-bed, air-blown atmospheric pressure gasifier. The gasifier was coupled with a hot, raw gas combustion system and iron ore pellet in. duration kiln. The gasifier is rated at 1.5 ton/h capacity of bituminous coal.

Jan 1, 1987

By Hon-Yim Ko

1972 constituted the second year of the projected five-year study on constitutive relations of coal. The schedule adhered closely to the five-year outline which is summarized in Table 1. This chapter is intended to serve as introduction and concise synopsis of the year's activities and results, which are presented in greater detail in the following chapters, which have been contributed by the individual researchers in charge of the various aspects of the project under study. Coal Sources, Material Procurement, and Sample Preparation Most of the studies performed during 1972 were done on coal from two sources: the Old Ben Mine #22 in Illinois, and the Bruceton Mine in the Pittsburgh seam of Pennsylvania, which may be considered typical of coal sources of economic importance in the Midwestern and Eastern part of the U.S. These two mines have proven to be reliable suppliers of coal material for our research. We have been able to establish good working relations with their personnel and feel that we can continue to count on their cooperation and help.

Jan 1, 1972

By J. P. Walsted

Offgrade chromite concentrate, with a Cr-Fe ratio of 1.3 to 1.4 has been successfully smelted to produce useful ferroalloys. The Cr-Fe ratio is not improved, but the alloys can be used without a too drastic change in normal steel-mill practice. The ordinary high-carbon ferrochrome has been successfully produced by smelting under highly acid smelting conditions. An alloy containing 50 percent chromium was produced at a power consumption of 4,490 kw.-hr. per ton of alloy. Alloys containing 20 percent silicon were made by direct smelting chromite concentrate and silica.

Jan 1, 1956

By Homer J. Ballinger

During the fall of 1943 and spring of 1944, the Bureau of Mines investigated nine secondary limonite iron-ore deposits in the Williamsville district of Wayne, Butler, and Ripley counties, Mo., by rotary-bucket and power-auger drilling test pitting, and trenching. Studies on beneficiating the ores were made at Bureau laboratories. Iron ore has been mined in Missouri since 1825, and iron mining reached its greatest development between 1870 and 1890. During this period, production averaged about 250,000 tons annually.

Jan 1, 1948

By M. Leva

WITH the development of new processes for the production of synthetic liquid fuels, an extensive literature search was undertaken to uncover fundamental relationships between fluid and heat flows and the operating variables of new types of converters. Examination of published correlations revealed that considerable uncertainty existed in the correlation of the operating variables of such equipment with the pressure drops which could be expected through packed and fluidized systems; correlations proposed in the literature differed from each other frequently by as much as 75 to 100 percent. Because new processes, especially more recent modifications of the original Fischer-Tropsch process, must compete with old, firmly established processes on the basis of unit product cost, the pressure-drop correlations in the literature were considered to be too inaccurate for use in calculating the energy required to pass fluids through packed beds. The following study was begun in 1946 to develop correlations that would be suitable for the design of new equipment in which fluids are brought into contact with granular materials. To arrive at general relationships, systems were chosen that did not involve chemical reactions, and a, particular effort was made to give the correlations only in terms of quantities that are ordinarily available from general process and design specifications.

Jan 1, 1951

By Hillary W. St. Clair

The reduction zone of the iron blast furnace is represented by a mathematical model of the chemical reactions and heat transfer that occurs between gas and solids during the deoxidation of iron oxide. The model consists of a set of equations and an algorithm whereby the equations may be solved to give the temperature and composition of gas and solids at any position in the reaction zone and at any time after a specified initial state. The model is applied to the special case in which ferric oxide is reduced by graphitic carbon and carbon monoxide produced by burning carbon in dry air. The rate of reduction, carbon consumption and maximum temperature are shown as functions of the temperature and rate of flow of the incoming reducing gas and external heat loss. The model of the reduction zone is the essential part of a general mathematical model for simulation of the iron blast furnace. The simulation model will serve as a research tool to be used in conjunction with an experimental or operating furnace. After the simulation model has been correlated with the real furnace, it is proposed that further experimentation be done mostly with the model. The real furnace will then be operated primarily to test and confirm the model.

Jan 1, 1967

By Martin A. Elliott

The Bureau of Mines began its investigation of the use of Diesel engines underground to provide technical information necessary to assist this development in the United States. It was considered desirable to furnish such assistance because successful European developments/ in this. field had indicated that Diesel mine locomotives might be safer than electric trolley locomotives. The Bureau has recognized for some time the importance of eliminating the hazards associated with underground haulage systems using bare trolley wires. For example, each year 30 to 40 fatalities occur as a result of electrocution by contact with bare trolley wires. In 1943 and 1944, 101 men were killed and extensive property damage occurred as a result of mine fires started by falls of roof grounding the bare trolley wires.

Jan 1, 1948

By S. H. Lorain

Tin mining on Seward Peninsula, Alaska, has been intermittently active since the early 1900's. Most of the recorded production (over 2,200 short tons of metallic tin) has been obtained from placer deposits, but recent production also has resulted from development of lode deposits associated with intrusive rocks occurring in the western part of the peninsula. Generally, the lode deposits containing tin minerals (principally cassiterite) are found in dikes, in granite masses, and in silicate zones in limestone overlying the granite. Both the placer and lode deposits have been of considerable strategic interest to the Government because of the almost total absence of a domestic supply of tin. The most important tin-lode deposit discovered to date is in the Cassiterite dike at the Lost River mine, on Cassiterite Creek about 85 miles northwest of Nome. This highly altered, rhyolite porphyry dike averages 12 feet in thickness, strikes N. 75° to 85° E., and dips steeply to the south; it can be traced on the surface for about 8,000 feet. Throughout its explored length of about 2,200 feet the dike everywhere contains some tin and tungsten in veinlets and disseminations; economic concentration of the are minerals, however, is confined to definite shoots. The ore minerals include cassiterite, stannite, hulsite, paigeite, wolframite, scheelite, and base-metal sulfides; gangue minerals include fluorite, boron silicates, and lithium-bearing minerals. Some ore minerals also occur in the numerous other dikes and in the granite and intruded limestone in and adjacent to the mine.

Jan 1, 1958

By G. E. McElroy

Tae purpose of this paper is to present types of charts adapted to aid in the graphic solution of fan-performance problems of selection and operation, and to urge the adoption of similar charts by the National Association of Fan Manufacturers as standard forms for presenting fan-performance data. As matters now stand, it is difficult for the average engineer to solve such problems because a laree number of variables are involved, and performance data are not presented in a manner that permits their direct application to many problems encountered in practice. The performance of any centrifugal machine is determined not only by the machine itself but also by the fluid-flow system on which it operates. Actual performance of centrifugal fans is therefore e matter of the type, size, and speed of fan, on the one hand, and of the relation of pressure to quantity of flow, as determined by the physical condition of the airway system, on the other.

Jan 1, 1936

By G. E. McElroy

[The purpose of this paper is to present type: of charts adapted to aid in the graphic solution of fan-performance problems of selection and operation, and to urge the adoption of similar charts by the National Association of Fan Manufactures as standard forms for presenting fan-performance data. As matters now stand, it is difficult for the average engineer to solve such problems because a large number of variables are involved, and performance data are not presented in a manner that permits their direct application to many problems encountered in practice. The performance of any centrifugal machine is determined not only by the machine itself but also by the fluid-flow system on which it operates. Actual performance of centrifugal fans is therefore a matter of the type, size, and speed of fan, on the one hand, anti of the relation of pressure to quantity of flow, as determined by the physical condition of the airway s: stem, on the other.]

Jan 1, 1936

By Vinit Mody

The belt conveyor is one of the major pieces of equipment for transferring bulk material in mining operations. However, considerable amount of respirable dust may be generated whenever the bulk material is loaded, dumped, or transferred. This report identifies and evaluates various dust control technolgies applicable to belt conveyors, and describes how an integrated systems approach can reduce dust emissions at a transfer point. Phase I of the program consisted of literature search and a critical evaluation of various dust control technologies. The work established that a comprehensive approach to calculating exhaust volumes for dust collection system does not exist. The parameters that affect the wet dust suppression efficiency were also reviewed. Based on the Phase I work, bulk material handling system and dry dust collection or wet dust suppression systems were designed and installed at a number of transfer points in a limestone processing facility, a surface mine selected as a field test site. Field test data were used to determine the validity of various exhaust volume calculations at the different transfer points. The field test data also formed the basis for the evaluations of the relative effectiveness of commercially available and wet dust suppression systems in controlling respirable dust emissions.

Jan 1, 1984

By F. S. Wartman

The presence of magnetite, either dissolved or suspended as solid crystals, in slags from the copper reverberatory furnace is a frequently mentioned cause of an abnormally high copper content in those slags. The presence of this oxide in the slag is to be expected, since it is present in appreciable amounts in both converter slag and roaster calcine which comprise a considerable proportion of the furnace feed. Magnetite is also a product of some of the furnace reactions. These abnormal losses result in several ways. Magnetite is supposed to favor the formation and retention of copper ferrite, in the slag. Crystals of solid magnetite suspended in the slag are objectionable-because they make the slag less fluid and often entrap globules of matte. Frequently these crystals settle into a layer at the slab-matte interface which may have such mechanical strength as to create a false bottom and interfere with furnace operation by preventing separation of matte from slag. Magnetite may, by crystallizing on the furnace bottom, build the bottom to such a level that the furnace can no longer be operated.

Jan 1, 1928

By M. A. Schellhardt

The Bureau of Mines has made periodic back-pressure tests on numerous gas wells in the Texas Panhandle field luring the past several years to study the delivery capacities of the wells under different pressure and operating conditions and to determine the relationships between pressures and rates of delivery from gas wells.4/ However, information regarding the intake capacities of gas-well systems is meager, end in projects involving- the flow of gas into porous-rock reservoirs it has been necessary to determine intake capacities of gas wells by trial. Accordingly the fundamental intake characteristics of natural-gas wells have been studied to develop a method for determining intake capacities under different wellhead pressures from data descriptive of the "output" or producing characteristic of the wells.

Jan 1, 1936

By E. W. Felegy

Since 1920, the Bureau of Mines and, other agencies have conducted numerous investigations of methods of communication for use in mines in times of disaster or emergency. The results of these investigations have been reported in various publications (3, 4; 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16). In November 1944, the Bureau of Mines resumed the study of emergency underground communications. Until March 1946, the program was directed toward reexamining methods of underground communication that indicated possibilities of success. Since April 1946, the principal interest of this investigation has been in methods of application of radio to communication in mines, low-frequency radio seeming to offer the most promise as a successful method of emergency mine communication. Results achieved in reexamining other methods and in the investigation or the application of low-frequency radio between November 1944 and September 1946 were reported previously in a publication entitled "Some Studies on Emergency Mine Communications".

Jan 1, 1948

By W. W. Adams

The United States Bureau of Mines, in cooperation with the National Send and Gravel Association conducted a safety contest in 1929 Among producers of sand and gravel. Only 26 plants were enrolled, as the contest was late getting under way. It is hoped that a ranch larger number of plants will be represented in the safety competition of 1930. Two trophies, both of which were provided by Rock Products magazine, were awarded at the end of the contest; one trophy was given for the best safety record among plants working 100,000 or mare man-hours during the year and the other for the beat record among plants working less than 100,000 man-hours. The trophies were presented to representatives of the winning, companies on January 29, 1930, at the annual convention of the National Sand and Gravel Association at Memphis, Tenn.

Jan 1, 1930

By W. E. Tournay

In accordance with a cooperative agreement between the Bureau of Mines, United States Department of the Interior, and the Linde Air Products Co., an investigation was made at the Bureau Explosives Testing Station, Bruceton, Pa., to develop suitable test methods for evaluating the performance and sensitivity characteristics of liquid-oxygen explosives. This report presents the results of the investigation. The unique nature of liquid-oxygen explosives necessitated both modification of standard techniques and development of entirely new test methods. The latter requirement was due to the fact that differences exist in the kind of information that must be developed for studying relative safety and performance properties of these explosives compared to that of fixed explosives.

Jan 1, 1949

By T. SPOLAN, G. W. Jones, R. E. Kennedy

Information relative to the explosibility of acetylene at elevated pressures and means of handling acetylene safely under these conditions is of considerable interest at present. American practice limits the pressure at which acetylene may be generated and distributed to poiIits of' use. The pressure in portable acetylene generators is 15 pounds per square inch gage. Tests made by the Bureau of Mines have shown that 15 pounds per square inch gage is too high to prevent explosiofiS of gaseous acetylene in the absence of air; in fact, dry acetylene gai can be exploded at pressures greater than 5.9 pounds per square inch gage. The Bureau has been interested in the explosibility of acetylene for many years because of its continued: use for illumination in many metal mines and its general use in cutting 1illd~--eldifigoperations in the mining maus-try.

Dec 1, 1948

By Clark P. Mangelsdorf

The report consists of two parts. In Part I is a state-of the-act study of roof truss technology as of January 1979. Included are a history of the truss concept, a review of analysis techniques, a record of hardware available and equipment used in its installation and numerous examples of user experience. Part II is concerned with a study of the role of friction in the behavior of a roof truss. The appendices include laboratory tests by the author.

Jan 1, 1979

By R. N. Johnson

This report is a summary of the work performed for the Bureau of Mines to evaluate the feasibility and desirability of a movable in-pit crusher combined with conveyors to substantially reduce or eliminate truck or train haulage in large open-pit non-fuel mineral mines. The report includes an introduction and summary of previous work, an analysis of movable crusher system components, a description of the selected system, a review of possible movable crusher system applications, and finally requirements for future work to bring about the general availability of such systems. It was clear from the program that there is a real need for movable in-pit crushers.

Jan 1, 1982