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By Natalie A. Sapola, Knox Van Dyke, Jean Rabovsky, Vincent Castranova, William H. Pailes, Melanie McPeek, Deloris J. Judy

"INTRODCJCTJONPlatelet activating factor (PAF) is a glycerophospholipid (1-0-alkyl-2-acctyl-sn-glycerol-3-phosphoryl choline) which has been shown to mediate a broad range of biological activities. 1·3 Its pulmonary actions include contraction of pulmonary tissue,4 secretion of leukotrienes from leukocytcs,5 airway constriction,6 pulmonary edema,7 and enhanced migration of neutrophils into the airspaces of thelungs.8-9PAF can be released from several different cell types, such as, basophils, neutrophils and alveolar macrophages, in response to a variety of particulates or membrane stimulants which include zymosan, calcium ionophore, phorbol esters, chemotactic agents, and endotoxin. 1~1 3 Therefore, PAF may play an important role in the development of pneumoconioses by mediating pulmonary responses of lung cells to a variety of occupational dusts. To investigate this possibility, we determined the effects of P AF on several physiological parameters of neutrophils, alveolar macrophages, and alveolar type Il epithelial cells.METHODSIsolation of CellsNeutrophils were isolated from human blood by dextran settling and centrifugal elutriation.14 Isolated neutrophils (93% pure) were resuspended in HEPES-buffered medium (145 mM NaCl, 5 mM KCI, 10 mM HEPES, 5 mM glucose, and 1 mM CaC12; pH = 7.4). Cell number and volume were determined with an electronic cell counter equipped with a sizing attachment.Rat alveolar macrophages were obtained by pulmonary lavage with ea2+, Mg2+-free Hanks balanced salts solution. 15 Alveolar macrophages (94% pure) were resuspended in HEPES-buffered medium, counted, and sized electronically.Rat alveolar type Il cells were isolated by enzymatic digestion for 35 minutes at 37°C with 40 µ/ml type I elastasc and 0.1 % collagenase and purified by centrifugal elutriation. 16.17 Type Il cells (92 % pure) were resuspended in HEPES-buffered medium for measurement of membrane potential, oxygen consumption, and trypan blue exclusion. Type Il pneumocytcs were resuspended in 0.1 M NaCl plus 0.05 M HEPES (pH = 7.8) to measure cytochrome P450-dependent activities and aggregation. Cell size and number were determined electronically."

Jan 1, 1990

By L. W. Stanger, Erich U. Petersen, William J. Tafuri, Donald M. Hausen, Douglas N. Halbe

Gold mineralization at the Mercur Mine was controlled primarily by structure and secondarily by lithology in Mississippian-age sedimentary rocks. Gold was localized where Sevier-age high angle northeast-striking faults are intersected by younger northwest-striking fault zones. The Lulu Graben is a northeast- striking fault zone composed of a south-dipping master fault coupled with subsidiary or antithetic faults. The Twist Fault zone, a sinuous, low-displacement , north-striking zone of fracturing, bisects the graben. Large- tonnage disseminated ore bodies formed east of the Twist Fault zone within silty, thin-bedded, bioclastic carbonates. West of the Twist Fault zone, gold was restricted to rock near peripheral faults surrounding a subvertical collapsed pipe developed within the graben. An overlying thick carbonaceous shale capped the ore zone. Presence of abundant limited- displacement faulting and of hydrothermal jasperoid is associated with cartonate-hosted disseminated gold. Conversely, increased fault displacement and widespread brecciation are associated with reduced dissemination of gold into normally receptive carbonates.

Jan 1, 1990

By R. Sivamohan, F. Huang

A mineral processing strategy developed for the finely and complexly interlayered calcite rich wollastonite, microcline, and iron-garnet ore of Jokkmokk, northern Sweden, gives an overall calcite recovery of 89.4% at a grade of 90.7% CaCO3. The wollastonite product assays 53.0% Ca- SiO3 at a recovery of 92.2%. The significant elements of the developed strategy are stepwise grinding, wet high intensity magnetic separation (WHIMS), reverse flotation and starvation flotation. Stepwise grinding avoids the overgrinding of soft calcite. WHIMS removes the colored iron-garnet impurity and thereby increases the whiteness of the product. Reverse flotation enables a simple flotation circuit and starvation `flotation helps to optimize the physicochemical conditions in cleaner flotation by giving rougher products of narrow particle size distributions. Moreover, with the reagent scheme developed in this work only one cleaner stage is necessary for the various rougher flotation products to be upgraded to give the foregoing results. In this paper, the strategy is presented in detail along with appropriate results.

Jan 1, 1990

By Ben L. Seegmiller

Specially truss systems? including the Intersection Truss®, Continuous Entry Truss®, Cutter Roof Truss® and Roktrus® have been used in many coal mines in the mid- west and western United States during the past four years. These truss systems offer greater strength and support than other standard trusses and many other support devices. Mining operations have found that speciality trusses can give effective long-term support in areas that must remain stable for many years. At some mines, the Intersection Truss® has become the most-widely accepted method of providing secondary support in potential problem areas. Other applications for specialty trusses have included longwall start- up and recovery rooms, arched roofs, access rock tunnels and tailgate entries.

Jan 1, 1990

By Linge H. G

The effect of sodium pyrophosphate and several polyacrylate deflocculants (Freevis 502, 528, 529 and 532; and Maxfloc 1015) on the gold loading on Calgon GRC22 and Norit R035l5 carbons was tested and found to be insignificant in a pulp free enviroument. These deflocculants can therefore be used in plants processing viscous gold pulps without fear of fouling the carbon.

Jan 1, 1990

Geological information plays a significant, cost effective role, in the Mt Whaleback iron ore mining operations. The geology and structure are complex. Good communication between the Mine Planning Production Scheduling and Quality Control Sections is the key to utilisation of geological information to its full potential.Drilling and pit face mapping are the two basic sources of detailed data sets which are processed to prepare up to date geological cross sections and benchwise geological plans. This information is used directly for the blast pattern design and production scheduling. Physical ore type estimation is also undertaken. Orebody models are generated from the geological information.

Jan 1, 1990

The mathematical modelling of rock fragmentation by blasting is one of the most difficult and challenging problems of applied mathematics. Not only is complex mathematics required but there is incomplete understanding of the basic physics and chemistry involved. The possibility of getting the physical basis of a model correct by simple mathematical and experimental procedures is demonstrated for the novel process of fragmenting rock by high-pressure arc discharges. While the importance of obtaining the correct physical basis for a model is emphasised, high-pressure arc induced fragmentation of rock is shown to be a powerful laboratory tool for the study of blasting.

Jan 1, 1990

The Escondida Porphyry Copper Deposit, located in Chile's II Region 160 Km to the southeast of the city of Antofagasta, is currently owned by Minera Escondida Limitada, a company comprising The Broken Hill Proprietary (57.5%), Rio Tinto Zinc (30%) a group of Japanese companies represented by Mitsubishi Corporation (10%), and the International Financing Corporation of the World Bank (2.5%) (Fig.l)By 1983, most of the reconnaissance drilling was completed and prefeasibility studies were regularly updated as new drilling results were reported and project concepts re-evaluated (Fig.2). In October 1982 the project was transferred from Exploration Management to Operations. By the end of 1984 project pre-development activities, including inpit development drilling, geological exploration, water resource definition, an underground bulk sampling program and the initial project feasibility report, were completed.

Jan 1, 1990

Jan 1, 1990

By J. E. Hamak

This publication contains analyses and related source data for 151 natural gas samples from 19 States. Of the total samples, 138 were collected calendar year 1989. The remainder were collected earlier, but releases to were not received until 1989. All samples were obtained and analyzed as part of U.S. Bureau of Mines investigations of the occurrences of helium in natural gases of countries with free market economies. This survey has been conducted since 1917. The analyses published herein were made by mass spectrometer and chromatograph.

Jan 1, 1990

Scientific drilling and blasting techniques are currently being presented to the mining industry as an aid in the overall optimisation process. The degree of success in the development of these techniques over the last ten years has prompted statements that generally relate to blasting becoming a science rather than an art. Many of the techniques are currently operated or at least analysed by scientists. As such, their use has been restricted to project type activities while the more routine activities associated with day to day mining has continued to be carried out by engineering rather than scientific staff. Some of the scientific techniques will remain legitimately as a project or an occasional use facility. Generally speaking a cost/benefit analysis at a particular mine will decide the level of use. This should logically highlight a number of techniques with potential of regular mine site use. Regular mine site use implies mine site analysis and hence the gulf between the scientist and mine operator/engineer must be addressed. There are all sorts of solutions and they are not mutually exclusive. One alternative could be to increase specialisation at the mines. With "career paths" becoming more formalised the trend would seem to be away from mine site specialists unless, for instance, this specialisation was provided by term secondment from research establishments. Another alternative could be the scientists themselves applying their developmental skills to "humanise" and "package" the projects in such a manner that they can be routinely used at mines.

Jan 1, 1990

By Richard H. Sailors

Data from full scale marked ball tests are used to demonstrate the effects of abrasion, corrosion, and impact on overall wear rate. The predominate wear mechanism need be identified before the optimum alloy can be chosen for the grinding media. Use of high chromium grinding media often results in increased mill efficiency due to shape retention. Thus, a benefit from energy savings can result as well as a reduction in wear rate. Converting from steel to east high chromium grinding media requires close association and cooperation between producer and consumer in order to properly conduct these studies.

Jan 1, 1990

By H. Lyn Bourne

This is the eighth annual tabulation of royalty information. Again this year, some of the older information has been deleted to make room for nearly 30 new entries. Several articles and publications have appeared recently that relate to mineral royalty or mineral valuation. R. B. Parsons wrote "Mining agreements, royalties and profits" (CIM Bulletin, November 1988). He distinguished between net smelter return (NSR) and net profit interest (NPI). Parsons used examples to show the difference between these royalty payment methods. Mining Engineering (January 1990) carried an article by H. V. S. Tingley entitled "Using business due diligence to help evaluate mineral deposits." The article identifies some factors that must be examined during mergers or acquisitions in the mining industry. Since each mining operation is unique, each has risks and opportunities that need recognition and evaluation. The author suggests that a team is necessary for a proper evaluation because no one person has expertise in all of the factors that must be examined. Also in January's Mining Engineering was "Limestone mining: Reserves and valuation," by B. C. Lewis and R. P. Moran. They presented two case studies of valuation of limestone reserves. One was a 109-hm2 (270-acre) parcel in West Virginia and the other a 121-hm2 (300-acre) tract in Alabama. The authors discussed risk, discount rates, and royalty methods as financial parameters in valuation of limestone reserves. Two papers were presented at the SME meeting in Las Vegas, NV in 1989 that bear mention. J.G. Russell's talk was entitled "Valuation of industrial

Jan 1, 1990

In the late 1970's and early 1980's a considerable number of large scale open pit mines were developed in N.S.W. and Queensland. At the time these mines were planned, the industry was characterised by rising coal prices, rising fuel prices, and a host of other labour and government constraints different to the situation today. Yet some mines have clearly been able to cope with this change much better than others. While one mine may now be expanding and profitable, its neighbour may still be labouring under painful adjustment processes. This paper examines the major reasons for this difference. It suggests more robust criteria for assessment of future projects to reduce their sensitivity to changes outside management control.

Jan 1, 1990

By John W. Ahlrichs, E. Daniel Baker, Erich U. Petersen, William J. Tafuri, Douglas N. Halbe

The combined Bootstrap and Capstone deposits, located in the Bootstrap subdistrict (Section 10, T36N, R49E, M.D.B.M., Elko County, Nevada), are approximately 27 miles northwest of Ca-1I: Nevada. The contiguous Bootstrap Capstone deposits are located along the northeastern and northern flanks of Round Mountain, a horst block separated by grabens from the sheep Creek Mountains to the north-northwest and the Tuscarora Mountains to the east. Open-pit-minable gold reserves as of December, 1989, were 13.27 million short tons with an average grade of .057 troy ounces gold per ton and an overall waste-to-ore strip ratio of 2.5:1. Ore zones in Bootstrap are concentrated along north striking high-angle dikes localized along faults, while ore zones at Capstone are strata form and structural, occurring at the Devonian limestone/siliceous sediment interface and in high-angle fault-filling dikes. Pre-ore faulting produced a complex structural setting for Capstone, dominated by strong northwest fault sets cross-cut by northeasterly structures. Alteration associated with both deposits is silicification with a-strong argillic overprint. Dike emplacement, which post-dates silicification, marked the onset of mainstage gold deposition and argillic overprinting of silicified lithologies. Gold displays an affinity for moderately argillized sedimentary and igneous lithologies. Mineralogic and geochemical analyses of rotary percussion drill samples show good correlation between gold, silica, antimony, and arsenic.

Jan 1, 1990

By Brinkmann J. R

The relative effects of the two basic mechanisms contributing to rock breakage during blasting, shock and gas penetration, are neither well understood nor well characterized, and need further clarification. Blasthole liner (BHL) tests separate the two effects, and by enabling direct measurement of borehole expansion give insight into the shock/gas energy partitioning in rock confinement. The hydrodynamic code DYNA2D is used to simulate the shock effect of the detonation of emulsion in a stainless steel lined hole, and the predicted expansion is compared with experiment. Workers in the past have neglected near-blasthole phenomena and have calibrated models based on stress measurements remote from the blasthole. Extrapolation back to the blasthole has inherent limitations, and indeed, one of the deficiencies of these models is that they have not been able to predict correct borehole expansions, as observed in BHL experiments. DYNA2D has been enhanced by the ICI group with a detonation model which resolves the explosive reaction zone. As a preliminary step towards the ultimate goal of devising a practical damage model, simulations are used to predict the maximum expansion that would take place if the rock were to remain undamaged. Various material parameters are investigated and it is shown that calculated liner expansions are appreciably lower than measured values for high rock yield strengths, while greater than values for low yield strengths.

Jan 1, 1990

By J. E. House

Creative ideas and endeavors require imaginative and positive responses, if they are to be reduced to practices. This lecture will define the plurastic roles of various technical disciplines which were important in the development of the LIX reagents. Specific personalities, facts, and events will be used to trace the development from an idea, to the exciting acceptance and practice of the technology. An objective analysis of the entire LIX reagent development, spanning twenty-five years experience of the author, will be given, these will be used as a basis for critical examination of how the various technical disciplines could improve their effectiveness in advancing future technologies.

Jan 1, 1990

"Cambior currently has nearly 80 exploration properties, acting as operator on about 60 of these. The company's exploration budget has increased to over $11,100,000 for 1990. On-going efforts recently yielded a new gold discovery on the Douay- Vezza property, a joint venture project with Inco and Vior. Cambior continues to seek out new opportunities, recently acquiring an option agreement on the Sleeping Giant project in Quebec and four new exploration agreements in the United States, through its Reno office. Other nearly-concluded joint venture agreements have also given the company entries into Indonesia and Guyana.SummaryWhen it acquired SOQUEM's assets on August I, 1986, Cambior also acquired interests in 45 exploration projects. The subsequent mergers with Aiguebelle Resources and Sullivan Mines in 1987 brought the total number of exploration projects to 83, most of which are concentrated in northwestern Quebec. Cambior's strategy emphasizes gold exploration, and exploration activities were, therefore, initially limited to the Val d'Or and Rouyn-Noranda mining camps, where Cambior has a large portfolio of properties. Approximately $25.8 million has been spent on surface exploration in this area since the formation of the company, resulting in the discovery of the Mouska deposit and four sub-economic zones on the Porcupine, Forbex, Bloc Sud and Flavrian project s. In 1988, Cambior became involved in projects in the United States to which the company expects to allocate about 38070 of its 1989 exploration budget."

Jan 1, 1990

The Copper Concentrator at Mount Isa Mines Limited treats approximately 6 Mt of chalcopyrite ore annually. The ore is currently sourced from the 1100 and 3000 orebodies at Mount Isa. Chalcopyrite is the only significant copper bearing mineral, with pyrite, quartz and dolomite being major gangue minerals. Ore is typically 10% chalcopyrite, 11% iron sulphides and 79% non-sulphide gangue. Copper ore is treated through two autogenous mills, two ball mills and a flotation circuit. The autogenous mills replaced a crushing plant, two rod mills and two primary ball mills during 1991. For routine analysis of concentrator performance, composite samples of mill feed, final concentrate and tailings are generated every 4 week period. All samples are sized and size fractions are assayed. Recovery of mineral species to the concentrate are then calculated for each size fraction. Sometimes liberation analysis was also performed by QEM*SEM (Quantitative Evaluation of Material by Scanning Electron Microscope).

Jan 1, 1990

By Marshall D. Himes, Erich U. Petersen

The Sheep Creek deposit near White Sulfur Springs, Montana, is a middle Proterozoic stratabound and strataform sediment- hosted massive sulfide containing 4.5 million tonnes (5.0 million tons) averaging 2.5% copper, and 0.1% cobalt in the upper sulfide zone (USZ) and 1.8 million tonnes (2.0 million tons) averaging 6% copper in the lower sulfide zone (LSZ). Mineralization is hosted in lower Newland shales and debris flow conglomerates in the graben controlled Helena Embayment of the Belt Basin. USZ mineralization is characteristically high in Cu, Co, Ni, Ba, As, Pb, and Ag. Mineralogically it consists of barite, pyrite, chalcopyrite, and tennantite with minor amounts of marcasite and various cobalt minerals. By contrast, the LSZ is higher in Cu, Ni, and Au and lower in Co, As, Pb, and Ag. Mineralogy of the LSZ consists of dolomite, pyrite, and chalcopyrite. In both zones significant amounts of cobalt, nickel, arsenic and copper are incorporated in pyrite rims. Tennantite controls the abundance of numerous trace elements in the ores. Fluid incluison data from hydrothermal USZ barite suggests that mineralization took place at temperatures in excess of 250°C, under relatively oxidizing conditions (f02 = 10-32+1) from moderately saline (1.1-3.5m), metal rich brines. The absence of barite in the LSZ suggests mineralization under more reduced conditions (f02 = 10.38+2). Mineralization was initiated following basin subsidence in excess of 400m. Contemporaneous with movement along a growth fault(s) was upward migration of hot metal-bearing fluids which permeated the loosely consolidated sediments and may have vented on the sea floor. The differences in the two zones may be explained by the effects of variations in local basin morphology and solution chemistry.

Jan 1, 1990