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By C. N. Logan

The Southern Company is one of the nation's largest electric utilities and is the parent firm of five operating companies: Alabama Power, Georgia Power, Gulf Power, Mississippi Power and Savannah Electric and Power. Another subsidiary is Southern Company Services (SCS) which provides engineering and technical sup-port to the five operating companies. This technical support includes the procurement and supply of over 40.9 Mt (45 million st) of coal annually for the 22 coal fired plants in the system. Approximately 80 percent of this tonnage is purchased under long term contracts and the remaining 20 percent is purchased on the spot market. The coal is principally supplied from Alabama, Illinois Basin and the eastern Appalachian coal fields. Most of the coal is delivered by unit train and barge but one plant in Alabama receives all its coal by truck and conveyor belt.

Jan 1, 1990

By A. H. Summers

The La Choya mine is located 55 km south of Sonoyta in northwestern Sonora, Mexico. Mineralization is controlled by a 40 meter thick thrust fault zone which created a permeable host for the metal-bearing hydrothermal solutions. The ore body is mined by open pit using wheel loaders and truck haulage. Gold and silver are recovered from low grade ore by heap leaching followed by carbon adsorption.

Jan 1, 1997

By Layson, W. C.

ACCORDING to the records, Phelps Dodge made its original entry into the production of copper in the oldest copper mines of Arizona at Morenci in 1881. The ore body now being mined as the Morenci open-pit, as outlined by churn-drill holes, diamond-drill holes, and underground workings, is estimated to yield 230,000,000 tons of ore averaging 1.06 per cent copper. This development will add 2,500,000 tons of copper to the 900,000 tons already produced in the district. Some five years ago preliminary development of the ore body began, with big-scale production planned including the erection of a new treatment plant to be built near the mine. Inasmuch as the Morenci open-pit was an entirely new project this required the grading of roads, establishment of mining benches, construction of railroad grades, building of railroad tracks, erection of shops, as well as the purchase of the necessary equipment to satisfactorily and economically maintain the schedules of production forecast. Along with the preparation of the main ore body it was also desirable to mine and deliver to an experimental mill a relatively small daily tonnage of typical ore.

Jan 1, 1942

By S. Pollak, J. Rickard

The Long Baseline Neutrino Facility Far Site in Lead, South Dakota is currently under construction and involves drill and blast excavation of the largest and deepest caverns in North America. This paper will review how the geotechnical risks are being managed through careful consideration of excavation sequence, completion of exploratory pilot tunnels, implementation of a robust instrumentation and monitoring program, and validation against the design. Aside from having a cross section of 5,900 square feet and being situated at a depth of one mile, the caverns also employ a unique permanent rock bolt solution which underwent a significant pre-production pull testing program involving varying installation methods and being subject to blast vibrations. The behavior of the schistose rock mass and performance of the ground support are being continually monitored throughout the construction phase.

Jun 13, 2023

By J Northfield, L Neesham

The GRE46 Underground Project lies beneath the environmentally unique and culturally endowed shore of Lake Cowal. The ore body is open both along strike and at depth and is currently defined to a strike length of 1.5km and depth of 800m. The Warraga exploration decline commenced in March 2019 and represents the first stage of the Project, which is expected to underpin production at Cowal Gold Operations (CGO) for a period exceeding 10 years. Mining operations at Cowal commenced in 2005, following a period of over 20 years of exploration and permitting. In 2015 Evolution Mining (Cowal) Pty Limited (Evolution) acquired the operation from Barrick Gold Ltd (“Barrick”). Barrick had a life of mine plan that anticipated a cessation of operations in 2024 at a processing rate not exceeding 7.5 Mtpa. Evolution have grown the regional endowment considerably and have a currently approved mine life out to 2032 with a currently approved maximum processing rate of 9.8 Mtpa. This paper examines the history, current status and future path of one part of that plan, the GRE-46 Underground Project. Topics for discussion include discovery, Mineral Resource growth under different ownership philosophies, planning, permitting and commissioning of an exploration decline and bulk sampling project, and integration with the possible future mine. Environmental sensitivities affecting regulatory approvals, timeframes, technical challenges, opportunities and solutions are discussed, along with the path required to fast-track production from the existing 14Mt, 1.4Moz Mineral Resource while complying with the requirements of modern, responsible project development stewardship.

Mar 15, 2021

By N L. Turner, K Ehrig, V Liebezeit, D J. Robinson, L L. Kuhar, N Francis

Conventional industry tests used to determine leach recoveries are often fully monitored and may be time-consuming and expensive. Such tests may be limiting in geometallurgical applications where large numbers of samples are required to be processed for characterisation of an ore deposit. BHP Billiton currently use a fully instrumented leach test for characterisation of Olympic Dam uranium-rich samples. Researchers at the Commonwealth Scientific Research and Industrial Organisation (CSIRO) were approached to develop an alternative to these full-scale leach tests that could allow for the ranking of samples in terms of their leachability. The novel geometallurgical test was required to use samples of small mass and be affordable and rapid.Three leach test protocols were pursued in developing the small-scale tests. Kinetic leach tests were performed using mild conditions at higher pH, low temperature and low oxidation reduction potential, moderate conditions at intermediate pH, temperature and oxidation reduction potential and aggressive conditions at lower pH, higher temperature and higher reduction potential.This paper presents results from 44 leach tests on 11 samples with varying uranium mineralogy. The developed small-scale tests correlate well with data from the more costly conventional industry laboratory tests, indicating the possibility of using this alternative test as a geometallurgical leach proxy. Simple regression analysis confirmed the importance of pH, reduction potential and temperature on uranium extraction. Experimental data were fitted to published leach models to predict uranium leach extraction for a range of operating conditions.The ultimate aim of the test work is to combine a limited number of large-scale calibration tests, a large number of small-scale geometallurgical tests and leach models for geometallurgical sample characterisation and evaluation of a wide range of scenarios or processing options.CITATION:Turner, N L, Kuhar, L L, Francis, N, Liebezeit, V, Ehrig, K and Robinson, D J, 2013. Development and testing of a small-scale uranium leach for geometallurgical applications, in Proceedings The Second AusIMM International Geometallurgy Conference (GeoMet) 2013 , pp 345-350 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Sep 29, 2013

By R. S. Dean

The original flotation reagents were certain oils selected for a combination of properties that occurred fortuitously. It was recognized quite early in the study of flotation mechanism that, in order to function, an oil must have an active group-one that differs from the remainder of the molecule in its affinity for water or the mineral particle. Wark4 gives credit for recognition of this elementary chemical principle to the senior author of this report.5 However, it was soon found that simple hydrocarbons could not be used as flotation reagents and that two of the functions, which were combined in the early flotation oils such as pine and eucalyptus, could be obtained in separate compounds and their relative intensity controlled to advantage. These two functions were called collecting and frothing.

Jan 1, 1944

By James W. Derrick

General widespread interest in fine coal cleaning circuits did not occur in the United States until the mid 1960's. Up until this period the relatively low price for which bituminous coal was sold did not justify for many operators the capital and maintenance costs associated with the beneficiation and drying of fine coal. However, with current growing interest in this area, the introduction of new types of process equipment along with modifications to existing components is occuring to maximize the recovery of coal fines. In 1973 Derrick Manufacturing Corporation introduced high frequency screening machinery into the coal industry. The first design consisted of a 4 ft. wide 18 ft. long single deck screen frame with three 100 mesh woven wire screen surfaces divided by repulping troughs for the addition of wash water. In addition, a special slotted rubber dewatering deck was installed on the discharge end of the unit to assure adequate dewatering of the screen oversize. This panel had nominal 25 mesh X 3.0" slotted openings. The machine was also equipped with a special high speed-low amplitude (3600 RPM .032" % AMP.) integral vibrator.

Jan 1, 1983

By C. C. White

Much benefit can be achieved by a mining company and a manufacturer if both parties can communicate effectively with each other and assist in product development; mutually beneficial ideas and products will develop. This communication can best be achieved if both parties have the opportunity of having on their respective staffs, specialists whose function is to improve the use of products used in mine development. Although a great wealth of roof control knowledge has long existed among mine operators, until recently there was not an abundance of joint development of roof control material by manufacturers and mine operators. This was perhaps due, in past lean years, to the preoccupation of mine management with other overwhelming problems that arise in mining. Manage¬ment had little time for the lengthy process of product development. Until recently, only a few of the largest mining companies had fulltime personnel devoted to roof control. A bolt manufacturer who is invited to work with an operator's roof control people in developing new material is lucky indeed in that he learns what is wanted and he acquires the benefit of the operator's knowledge and experience. He has only to come up with a satisfactory product at an acceptable price - which is not always easy: The development of new products is usually costly and time consuming, and many new products fall by the wayside. In the case of point anchors, however, this product is here to stay. The advantage of point anchors over mechanical anchors is now a proven fact. This advantage is due to less bleed off and higher ultimate load capacity of the resin point anchors. Point anchored bolts have proven to be superior to fully grouted bolts in many areas. We at Birmingham Bolt Company are fortunate in that we have been involved in joint efforts to develop point anchors with several coal companies from whom excellent advice and direction was received. It is appropriate to mention before continuing that the use of point anchors began in the 1960's in Europe and became widespread only recently in the United States. They fall in two categories, point anchors and combination point anchors. These categories have been defined by the Bureau of Mines as follows: (1) point anchors having 24" of grouted length and (2) combination anchors having 24" or more of grouted length. In the present nomenclature, all are anchored with resin or some sort of cementing compound between the rebar or tensioned element and the wall of the hole. The latest development includes an expansion shell as well as rebar, the purpose of the expansion shell being to facilitate installation without the delay necessary in use of types that require a waiting periond for setting of the resin before tightening. (See figures #1 and #2.

Jan 1, 1982

By J. E. Dreier, R. E. Scheffel, A. Guzman

"This paper outlines a comprehensive, cost-effective testing program for the acid-ferric sulfate heap leaching of oxide, supergene and primary copper ores. It is based on extensive experience in copper heap leaching and uses the many technological advances in the field developed over the past several decades. The approach described requires firstly a detailed resource evaluation, then a hydrodynamic characterization of representative samples and, finally, a focused metallurgical testing program. The principles communicated here can be applied to other acid leachable minerals. The program varies considerably from conventional testing in its disciplined, orderly, step-by-step approach, its application of hydrological and chemical principles to leaching, and its reliance on fewer, more tightly controlled column tests. The purpose of the test program is to optimize the financial, time and other resources devoted to the program, while minimizing the financial risks to the development company or companies and the project funding providers. IntroductionThe major goal of any process development testing program should be the successful implementation of the project. With respect to heap leaching, the metallurgical testing program plays a critical role in the larger objective, as described in Scheffel (2013, 2014). McNulty’s series of papers (1998, 2004, 2014) confirm that the success of any project is directly proportional to the extent and quality of the testing program on which the process is designed.Therefore, a key development objective is to conduct a well-focused metallurgical test program. While the primary focus of this paper is copper, the acid leaching of any substance would benefit from a similar approach.This paper addresses primarily the sulfate system, which is compatible with the bioleaching of sulfide minerals. Nicol et al. (2011) described the advantages of the chloride leaching of copper sulfide minerals. United States patents Nos. US 2009/0173188 A1, US 8,597,933 B2 and US2015/0232963 A1, assigned to BHP Chile Inc. and BHP Billiton S.A. Ltd, describe methods for both the oxidative and nonoxidative leaching of primary and secondary copper sulfides. Reyes (2013) and Ipinza and Flaquer (2014) described commercial applications of chloride-based heap leaching. The testing disciplines discussed in this paper will also apply to the development of an acidic chloride leaching system."

Jan 1, 2016

By Jose Agapito

Roofbolts with expansion anchors have been used at White Pine for more than twelve years, but always with an understanding that their performance was not entirely satisfactory. Some bolts fell out, some were obviously loose, and, when roof failures did occur, very few bolts actually broke. Obviously, there was an anchorage problem. A program was started in May, 1967, to define the problem and to solve it. This paper describes briefly those parts of the program which led to the development of a roofbolt assembly which performs much better in the medium-hard rocks at White Pine. As a result of the changes, significant improvements were found in the torque:tension, tension loss, and pull tests.

Jan 1, 1970

By P. Wearden, K. Bryner, K. Vrana, V. Castranova, R. Dey, R. Reist, J. Blackford

"Summary: Fibroblast proliferation and enhancement of collagen synthesis are key steps in the development and progression of pulmonary fibrosis. The current investigation presents a fibroblast proliferation assay to detect the release of competence factors from pneumocytes. The specific objective of this study was to define cell culture conditions for fibroblasts that would allow selective detection of competence factors in test media. The results indicate the following: (a) fibroblasts should be cultured for 2 days in plasma-free medium rather than 2% plasma to assure complete quiescence; (b) 1% plasma was optimum for producing progression activity for the bioassay of a competence factor, while 0.5% plasma did not produce sufficient progression activity (yielding false negatives) and 2% plasma often contained significant competence activity (yielding false positives); and (c) fresh plasma should be used since the progression activity of plasma was adversely affected by freezing and thawing. Under these conditions, this bioassay can be employed with either rat or human lung fibroblasts to detect competence factors such as platelet-derived growth factor (PDGF), at levels as low as 25 ng/ml.Fibrotic lung disease, as a consequence of occupational exposure to silica dust. is characterized by the development of concentric hyalinized nodular lesions in the lung and the progressive loss of pulmonary diffusion capacity. Proliferation of pulmonary fibroblasts and enhanced synthesis of collagen by these pneumocytes have been shown to be key steps in the development of chronic silicosis ( 1 ). The regulation of lung fibroblast proliferation by cytokines released from alveolar macrophages may be an important pathogenetic mechanism in the development of the fibrotic process (2). Some cytokines stimulate fibroblast proliferation by activating specific phases of the cell cycle (3,4). In particular, platelet-derived growth factor (PDGF) promotes fibroblast proliferation by inducing the movement of quiescent (G0 ) cells into the G1 phase of the cell cycle (5). Insulin-like growth factor (IGF) and transforming growth factor-P (TGF-P). on the other hand, regulate the rate of transition of fibroblasts from G 1 into the S phase (5,6). These two classes of cytokines have been termed competence and progression factors, respectively. One approach used to examine the release of cytokines from macrophages is the fibroblast proliferation assay in which quiescent fibroblasts are exposed to culture supematants from macrophages exposed to various stimuli. In most of these assays, the supernatant contains fetal calf serum (FCS), which provides the competence factor(s) necessary to facilitate the proliferation of fibroblasts (7-9). Recently, a fibroblast proliferation assay using platelet-poor .plasma [lacking competence factor(s)] as a substitute for FCS bas been described (I 0, 11 ). In this assay, the release of a competence-inducing PDGF-like growth factor from rat and human macrophages can be distinguished from other cytokines that act as progression factors."

Mar 1, 1992

By J Caron, M Athayde, F Lavoie, R Joyce

Decarbonisation has become a major challenge for the global steelmaking industry, turning towards new technologies aimed at carbon footprint reduction, which on its own accounts for approximately 9 per cent global emissions. The iron and steel industry represents a ‘hard to abate’ sector, where much of efforts are currently being deployed into initiatives aiming to decarbonise the ironmaking through the use of green hydrogen, carbon capture utilisation and storage and state-of-the-art operation of current technologies, while little efforts being deployed to find carbon-efficient solution to iron ore burden preparation, where high-grade iron concentrate will increase in importance to ironmaking regardless of the chosen reduction route. Quebec Iron Ore (QIO), a subsidiary of Champion Iron Limited (Champion), produces high-grade hematite concentrate with one of the lowest carbon global footprints. Still, QIO is partnering with its clients to the development of burden solutions to minimise CO2 emission, in the seek for a decarbonised steel. In a strong technological partnership, Binding Solutions Limited (BSL) has developed a novel, coldbinding technology to provide a cleaner, more cost-effective alternative to induration. The technology allows miners and steel producers to reduce Capex significantly and reduce energy consumption and CO2 emissions by 90 per cent. QIO and BSL have partnered to adapt the disruptive cold binding technology developed by BSL to QIO’s concentrate to produce a high-quality low emissions iron ore agglomerate. This paper describes the efforts taken to further develop BSL’s cold binding technology and its application to QIO’s high-grade iron ore concentrate to produce a hematite cold bonded briquette (hCBB) showing comparable performances with high quality seaborne fired pellets.

Nov 8, 2021

By John C. Leighton, C. O. Brawner, Doug Stewart

"Despite the availability of established, sophisticated methods for planning and designing stable slopes in rock, comparatively little attention is usually paid to the problems of carrying out the excavation. Blasting should be carefully planned to obtain optimum fragmentation as well as steep, stable working and final pit walls. The principal difficulty facing a blast designer is the lack of prior information about the many critical blasting characteristics of the rock mass. The common practise of trial-and-error lasting will eventually lead to a suitable program, but must be repeated time after time in variable geology. This frequently results in many blast-damaged slopes. Recent research indicates that monitoring drill performance will yield a Rock Quality Index which correlates to a Powder Factor value. The drilling can provide a continual supply of data, reflecting changes in the rock mass which enables the selection of an economical powder factor.IntroductionWhen planning to excavate a large-scale rock slope, engineer s will generally spend considerable effort to produce a safe, feasible and economical design. Much time will usually be spent on the field map ping, 'structural geologic studies, surface and subsurface hydrology, determination of strengths and effective friction angles of discontinuities, and finally checking stability with the aid of mathematical and analytical models. If the rock cut is to be along a transportation corridor, the prime justification for this time and effort is to produce a clean, stable slope which will be safe for those travelling or working beneath it. For the walls of an open-pit mine, there is the additional economic incentive to maintain the steepest stable slope angle for the minimum stripping ratio (Stewart and Kennedy)."

Jan 1, 1982

Cannington Mine is an underground, hard rock, metalliferous mine located in North-Western Queensland, Australia. Weld mesh is installed to prevent the failure of rock from between the installed reinforcement elements. Corrosion reduces the capacity and life expectancy of mesh and presents a real hazard to underground personnel and equipment as it reduces the effectiveness of the support system. Corrosion influences the economics of the mining operation through the need to conduct rehabilitation of the ground support which involves re-installing new mesh or shotcreting over the affected mesh to protect it from further corrosion. The requirement for rehabilitation is determined by the geotechnical engineer based on an individual visual assessment with little or no engineering input. It was identified that a more quantitative method was required that considered the safety and economic risks involved. A project was undertaken to develop a simple method to evaluate corroded mesh and to provide selection criteria for rehabilitation. A weld mesh corrosion classification has been developed that relates the average wire diameter of corroded mesh to the remaining capacity of the mesh. Accompanying selection criteria provides recommendations as to when rehabilitation may be required based on the estimated residual mesh capacity, the remaining development life, and the level of personnel exposure.

Nov 25, 2010

By Donna Guillen, Matthew Lehar, Sebastian Freund, Jennifer Jackson, Helge Klockow

"Research and development is currently underway to design an Organic Rankine Cycle (ORC) system with the evaporator placed directly in the hot exhaust stream produced by a gas turbine (GT). ORCs can be used to generate electricity from heat that would otherwise be wasted, thus producing carbon-free energy. In conventional ORC configurations, an intermediate oil loop is used to separate the hot gas from the flammable working fluid. The goal of this research effort is to improve cycle efficiency and cost by eliminating the pumps, heat exchangers and all other added cost and complexity of the additional heat transfer loop by developing an evaporator that resides in the waste heat stream. Direct evaporation – although simpler and less expensive to implement than indirect evaporation of the working fluid – has historically been avoided due to a number of technical challenges imposed by the limitations of the working fluid. The high temperature of the hot exhaust gas may cause decomposition of the organic working fluid and safety is a major concern due to the high flammability of some of these working fluids. The research team has addressed these challenges and developed a new direct evaporator design that can reduce the ORC system cost by up to 15%, enabling the rapid adoption of ORCs for waste heat recovery. The ORC system is intended to integrate with the GT either as a retrofit or to be marketed as a single package, thus maintaining the manufacturer’s warranty.IntroductionWaste heat from turbines and engines used in industrial applications along with waste heat from industrial processes are exceptionally abundant sources of energy. If even a fraction of this waste heat could be economically converted to useful electricity, it would have a tangible and very positive impact on the economic health, energy consumption, and carbon emissions in the U.S. manufacturing sector. Land-based gas turbines are used in a broad range of applications to produce both shaft and electrical power. Most commonly known for generating electricity either as peaking units or as base load units, they are also used to directly drive pumps, compressors or other machinery requiring shaft power. Simple cycle gas turbines have the advantage of a short startup time relative to coal-fired and nuclear units, however, they incur a significant penalty on their efficiency. Large frame gas turbines usually are combined with bottoming steam-based Rankine cycles to increase the overall efficiency of the system and thereby improve their cost performance. Small-frame gas turbines with exhaust temperatures around 500°C could in principle benefit from steam bottoming cycles, but rarely use them in practice because of the high capital cost of the steam system. Particularly for base load small frame gas turbines, akin to those used in pipeline applications, an increase in efficiency is highly desirable."

Jan 1, 2011

By D. A. Peterson

Laboratory testing was completed to determine the effectiveness of a fiberglass cable bolt (FCB) as a cuttable rock support for a continuous, hard-rock mining method. The FCB consists of four Polystal tendons combined in a node/antinode fashion, with polyvinyl chloride (PVC) spacers forming the anti-nodes. The largest ultimate pull-out load achieved by the FCB was 22 t (48,400 lb) at 89% of the tendons' theoretical pullout load. This premature tendon failure is accredited to: • differential stresses within the tendons and • differential tendon displacement. An increase in pull-out resistance for a given embedment length is due to: • increased bond area, • reduced interfacial shear and • "wedge" effect. The critical embedment length was found to be 40% less than for conventional steel cable bolts (SCB) at a 127-mm (5-in.) node spacing. An FCB can have up to a 92% increase in load-carrying capacity over a conventional SCB at equal embedment lengths. The load carrying capacity is equivalent to SCB at a 960-mm (37.8-in.) embedment length. Though the FCB is 7.5% more expensive than the conventional SCB (installed), this cost may be offset by increased performance. FCBs are a potentially viable support alternative for continuous hard-rock mining.

Jan 1, 1993

By P. Wearden, K. Bryner, K. Vrana, V. Castranova, R. Dey, R. Reist, J. Blackford

INTRODUCTION Proliferation and enhanced synthesis of collagen by pulmonary fibroblasts have been shown to be key steps in the development of chronic silicosis (Goldstein and Fine, 1986). The regulation of lung fibroblast proliferation by cytokines released from alveolar macrophages may be an important pathogenetic mechanism in the development of the fibrotic process (Kelley, 1990). One cytokine, platelet-derived growth factor (PDGF), promotes fibroblast proliferation by inducing the movement of quiescent (Go) cells into the C1 phase of the cell cycle (Chen and Rabinovitch, 1989). Others regulate the rate of transition of fibroblasts from Gl into the S phase (Leof et al., 1982). These two classes of cytokines have been termed, respectively, competence and progression factors. One approach used to examine the release of cytokines from macrophages is the fibroblast proliferation assay in which fibroblasts are exposed to culture supernatants from macrophages exposed to various stimuli. In most of these assays, the supernatant contains fetal calf serum which provides the competence factor(s) necessary to facilitate the proliferation of fibroblasts (Bitterman et al., 1982; Bitterman et al., 1983; Elias et al., 1988). Recently, a fibroblast proliferation assay using plateletpoor plasma (lacking competence factor(s)) as a substitute for fetal calf serum has been described (Kuman et al., 1988; Bauman et al., 1990). In this assay, the release of a competence-inducing PDGF-like growth factor from rat and human macrophages can be distinguished from other cytokines that act as progression factors. In order to obtain more consistent results and with the ultimate goal to be able to discriminate between the effects of competence factors as opposed to progression factors, we have conducted experiments to determine the appropriate concentrations of plasma and PDGF required for imparting competence in the fibroblast proliferation assay. We tested lung fibroblast cells obtained from explants of rat lung tissue and also a fetal human lung fibroblast cell line obtained from American Tissue Culture Collection (ATCC153). MATERIALS AND METHODS Fibroblasts Specific pathogen-free, male Sprague-Dawley rats were use in some studies. Animals were given a lethal intraperitoneal dose of sodium pentobarbital. Fibroblasts were isolated by chopping the lung in enzymes that digest the connective tissue but liberate lung cells for further study (Rabovsky et al., 1989). After digestion, the remaining lung tissue suspension was filtered through two layers of sterile gauze and centrifuged to recover lung fibroblasts. These were resuspended in culture medium that contained 10% fetal calf serum and distributed to culture plates for growth. In other experiments, a human fetal lung fibroblast cell line, obtained from American Type Culture Collection, Rockville, MD, 20852, was used instead of rat lung fibroblasts. In these cases, a 1 ml ampule containing human fetal fibroblasts was plated into a tissue culture flask containing medium plus 10% fetal calf serum. For both types of fibroblasts, culture medium was changed 3 times per week and cultures were incubated at 37°C until confluent. Harvested rat and human lung fibroblasts were quantified using an electronic cell counter equipped with a cell sizing attachment (Coulter Electronics, Inc., Hialeah, Florida). Tritiated Thymidine Incorporation The basic procedural outline of Kumar et al. (1988) was used with modifications to evaluate tritiated thymidine incorporation into fibroblast DNA following exposure to PDGF and plasma. Both rat and human lung fibroblasts were plated at 50,000 cells/ml at a density of 250,000 cells/25cm2 culture plate. Cells were quiesced for 4 days with 2% rat plasma. As the assay was refined, fibroblasts were quiesced in plasma-free media for 48 hrs, since the mitogenic activity of 2% plasma was variable. Test medium was applied for a period of 6 hrs, followed by a 24 hr tritiated thymidine (lµCi/ml) labelling period in plasma-free media. Medium alone was used as a negative control and media with 10 or 20% fetal calf serum was used as the positive control for rat and human fibroblasts, respectively. Cell Quantification and Measurement of Mitogenesis Twenty-four hours after the addition of tritiated thymidine, the fibroblasts were washed with 5ml of fresh serum-free media, centrifuged and resuspended in phosphate-buffered saline. The cells were dissolved in 0.5m1 of O.1N NaOH and radioactivity determined in a beta counter. Incorporation of trititaed thymidine as an index of DNA synthesis was expressed as DPM/fibroblast. RESULTS In the present study, we quantified mitogenic potential by monitoring the incorporation of tritiated thymidine as

Jan 1, 1991

By M. M. Masood, G. Y. Raju, T. Verma

The inverse velocity method has proven to be an effective approach for predicting slope failures in surface mines by analysing displacement monitoring data. However, the accuracy of inverse velocity method predictions is significantly affected by instrumental noise and natural environmental variations, which influence the identification of different deformation stages. To enhance predictive accuracy, this study applies and evaluates three filtering techniques to velocity time series data: Exponential smoothing filter, short-term smoothing filter, long-term smoothing filter and also compares it to raw data (no filtering). A refined prediction framework, that is, filtered inverse velocity method analyser, is proposed to improve slope failure forecasting in surface mining operations. The results demonstrate that filter selection plays a crucial role in optimising failure time predictions, offering valuable insights for geotechnical monitoring and early warning systems in surface mines.

Sep 1, 2025

By P. Mendoza, R. Siwale, H. Amini, R. Silva, M. Richards, V. Ngcoza, D. Rivera, C. Canaza, R. van Reenen

Development of a realistic flotation model to predict its performance is of paramount importance to the processing plant and operators, a model that accounts for predictive and no-predictive maintenance simulating individual equipment downtime and the effect of it in the metallurgical performance on the flotation bank with final recoveries and grades has a huge advantage on optimizing the flotation circuit/bank in terms of mechanical and metallurgical side. The Model was developed in a dynamic environment that allows for a better and more realistic simulation of the flotation bank. The maintenance model accounts for the Failure rate, Mean Time Between Failures (MTBF), Mean Time to Failure (MTTF) and Reliability (R(t)) those characteristics are combined to a multi-compartment process model that consists of a slurry recovery model, two options of froth recovery models, entrainment and carry capacity as a final check for the system. In addition to the maintenance and process model, a dynamic dart valve model was added to the simulation in order to have a realistic model to control the slurry level at the flotation cell. The paper goes over a study case for a current flotation operation trying to explore all the elements and the simulator to optimize the Rougher flotation bank.

Mar 2, 2022