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By Kathy Pomeroy

Sharing?? l Maybe not the first image that comes to mind when we think about the historical corporate mind set and track record of many corporations ? ! A Fundamental Change in Relationships l From a worldview of independence to one of recognized interdependence l Collaborative action with communities for long range mutual goals l Acceptance of greater accountability for the whole l Community and government relationships based on trust, mutuality, respect for human rights, equity, sustainable agreements

May 1, 2002

By B. Galy, L. Giraud

"This paper compares Canadian provincial mining safety regulations addressing hoist safety, automatic hoisting, and shaft obstruction. The regulations are quite similar among provinces, with only slight differences. Risk-mitigation strategies used in other industries are discussed, including their applicability to mine hoists. The specific case of software safety is introduced through examples. The mitigation of software failure is based on the use of the software lifecycle as recommended by the International Electrotechnical Commission (IEC) 61508 standard. Finally, ways to improve hoist safety are proposed.RÉSUMÉ Le présent article compare entre elles les diverses réglementations provinciales canadiennes concernant la sécurité des machines d'extraction, le levage automatisé et les obstructions dans les puits. Les réglementations sont assez semblables entre les provinces, mais elles comportent de légères différences. Les stratégies d’atténuation des risques utilisées dans d’autres industries sont abordées, incluant la possibilité de les appliquer aux treuils de mines. Le cas spécifique de sûreté des logiciels est abordé par des exemples. L’atténuation de la défaillance des logiciels est basée sur l’utilisation du cycle de vie du logiciel, comme cela est recommandé par la norme 61508 de la Commission électrotechnique internationale (CEI). Des moyens d’améliorer la sécurité des treuils sont également proposés."

Jan 1, 2016

By David E. Ngandu

Paper Withdrawn at Time of Printing

Jan 1, 1996

By Rob Penczak

Éléonore Presentation Overview ? Location & Infrastructure Éléonore Property Regional Geological Setting Discovery & Exploration History Geological Setting of Deposit Types Roberto Au Deposit Lac Ell Cu-Au-Ag Occurrences Synergies & Strategic Alliances

May 1, 2006

By R. A. D. Pattrick, D. A. Polya, D. J. Marsh, J. -J. Bao

"The utility of high-density stream sediment and stream water sampling to the exploration for silver deposits was investigated by the study of the epithermal Ag-Au base-metal prospect at Lagalochan in western Scotland. The geology of Lagalochan is dominated by a calc-alkaline Caledonian intrusive complex emplaced into Dalradian Supergroup rocks (Harris et al., 1988a). The complex consists of subvolcanic porphyrytic rocks associated with intense hydrothermal alteration and brecciation. Early Cu-Ag-Mo-rich mineralization is found in the core of the complex with later Pb-Zn-Ag-Au-As-Sb-rich mineralization toward the margins (op. cit.).Stream sediment sample analysis spatially resolved the Cu-rich and Ag-rich mineralization. Ag and Cu anomalies relative to local background values were found in all size fractions analyzed (-125µm, +125 µm, +180 µm, +250 µm) but the more pronounced anomalies were found in the -125 µm fraction. The coarser fractions generally revealed more erratic but longer dispersion trails. The separation of Cu-rich and Ag-rich mineralization is also apparent in the distribution of relatively high dissolved Cu and Ag in stream waters, particular when expressed relative to the solute load as Cu/TDS and Ag/TDS.The mineralization at Lagalochan is indicated by Ag, Cu and Pb stream sediment and water concentrations that are anomalous with respect to local backgrounds, but are difficult to distinguish from regional backgrounds. This emphasizes the further potential of high-density stream water sampling,in particular, as a viable geochemical exploration tool on a sub-regional scale for epithermal depositsin relatively unpolluted upland terranes."

Jan 1, 1995

By Jamie W. Pardy

The objective of the Canadian International Development Agency program is to facilitate the efforts of the people of developing countries to achieve self-sustainable economic and social development in accordance with their needs and environment. The British Columbia Ministry of Energy and Mines (BCMEM) is the executing agency for the four-year Peru Minerals and Metals Public Sector Assistance Project which began in December 1998. The primary beneficiary is the Ministerio de Energía y Minas del Peru (PMEM). The project is designed to address mine health & safety, environmental management and mineral resource information. Project activities currently underway include joint development of: an inspection system, a mine rescue system, an enhanced and e-Commerce capable mineral information website, environmental guidelines for industry and standardized ministry evaluation criteria for environmental impact assessments and closure plans. In addition, reports on management options for mineral concentrate transportation, storage and handling, and on mine reclamation security policy have been delivered at workshops.

May 1, 2001

By J. C. O'Rourke

"Gibraltar Mines Ltd. has been operating its open pit copper mine for fifteen years. In that time over 140 million tons of waste and low grade material has been placed on the mine waste dumps. Laboratory and in-situ testing indicated that enough leachable copper was recoverable from the dumps to justify a leaching operation which would include the construction of a solvent extraction-electrowinning plant. The plant, which was commissioned in October, 1984 was designed to process 3,000 usgpm of dilute copper solution to produce 5,000 tons per year of high quality cathode copper.This paper deals with the start up and initial year of operation of Gibraltar's SX-EW plant. The three areas: leaching solvent extraction and electrowinning are presented with emphasis on the innovations which were made to help overcome the problems unique to die Gibraltar operation.THE LEACHING CIRCUITThe mines waste dumps are leached to produce a pregnant copper solution as feed to the SX-EW plant. To achieve this the dumps are sprinkled with a mildly acidic solution which percolates through the dump. In travelling through the dumps the solution contacts the surfaces of the liberated copper minerals and disolves the soluble copper into the form of copper sulphate. The leaching reaction is achieved by a combination of bacterial action to oxidize the suphides and solublization of the copper into the acid solution.For the bacterial action to occur the dumps must be at or near the ideal pH of 1.9 - 2.1 and the necessary elements of the reaction must be present. Because a bacterial reaction is involved there is a lag time between the time when the conditions for bacterial growth are achieved and when the bacteria are in their active growth phase. Laboratory tests with Gibraltar ore indicated that bacterial action takes two to three months to reach its maximum rate. See figure 1.The expected lag time for the planned rate of bacterial leaching prompted Gibraltar to start irrigating the dumps in late June 1986 for a plant start up in early fall. The lag time proved to be longer than expected and the dumps took until November to start producing copper at the expected rate. See figure 2."

Jan 1, 1988

By Carlos Nieble

Ferteco Mineracao, belonging to the CVRD group, is one of the several iron ore mines in the south east of Brazil. Some of these mines have pit walls of over 350-m height and operations under difficult geo-technical conditions are steadily increasing. In order to mine the 15 million tonnes of high grade hematitic ore remaining in the Fabrica pit, Ferteco had to deal with the following restrictions: Warrant power to its concentrator and pellet plant, relocate the load-out rail road loop, stabilise a poor phillyte slope, relocate a creek on a bench, lower the water table and mine at maximum angles at a slope with phillyte and loose itabirites directly under the rail road loop. Considering these aspects, 3 stages of operations were designed, considering a safe operation, but with the lowest possible security factors at the last mining stage, before the pit would be filled in again with tailings. Stage one above the rail road loop and below the high tension power mast, where the poor phillyte slope was secured by a flexible retaining wall, using old rails and anchors up to 27 meters (80ft) with a working pressure of up till 30 tonnes and stage two with different slope angles, and deep wells, high wall blasting perpendicular to the highwall with relief holes and rerouting the creek in steel half culvert and stage three, the filling in with tailings and recuperation of the deep well pumps. Following studies and analysis were made: Geotechnical and geological studies of all rock formations including rock strength test, a hydrological study to define the lowering of the ground water level, slope stability analysis for every bench and all possible combination of benches, definition of blasting parameters close to the pit slope, a monitoring plan, including topographical movements, vibrations due to blasting, piezometers and pressure cells as well as a plan how to fill up the pit again with tailings in combination with the rising of the ground water level. A close co-operation between the geo-technical consultant, pit operations, the blasting contractor and the geological department resulted in an operation without any incidents, lowering the pit with an additional 3 benches and mining an additional 5 million tonnes of high grade ore.

May 1, 2003

By C. B. Mapes, E. C. Dowling Jr.

"To reduce concentrate dewatering and drying costs, the Concentrator Division at Phelps Dodge Morenci, Inc. investigated available filtration technologies. Numerous methods were explored, including: drum, disk, belt, pressure, hyperbaric, and ceramic media filtration. An economic evaluation of the individual filtration technologies indicated the advantages of ceramic media filtration for Morenci concentrates. This paper discusses the technological development culminating in the first full scale application of ceramic media disk filters in North America. Low moisture contents are obtained at high production rates and greatly reduced operating costs.INTRODUCTIONPhelps Dodge commissioned the Morenci Concentrator Filter Plant in 1942 with four 8'6"" Dorr-Oliver cloth disk filters. That year, the filter plant processed 265,537 tons of concentrate grading 20.5% Cu. The filter cake production averaged 9.3% moisture. In 1944, the Extension Filter Plant commenced operation with three additional 8'6"" Dorr-Oliver cloth disk filters. This coincided with the expansion of the concentrator. Production that year totaled 451,567 tons of concentrate grading 23.8% Cu. Moisture averaged 9.4%.Through the years additional filter units have been added in response to increased concentrate production. An Eimco drum filter was installed on the extension side and an additional Dorr-Oliver disk filter was installed on the original side in the 1950's. In 1961, two 8'6"" Peterson disk filters were installed, one on each side to replace two worn-out DorrOlivers. The installation of four 10xl2 foot Peterson drum filters was completed in 1974, coinciding with the Metcalf Concentrator startup. An Eimco belt filter was installed later.The greatest change to concentrate dewatering at Morenci occurred in 1963 with the addition of a 10x60 foot rotary gas fired dryer. The installation also included a number of conveyors to deliver filter cake from both plants to and from the dryers. Other ancillary systems included dust scrubbers and their slurry pumps. The commencement of drying was undertaken due to the rapid increase in cake moisture as a result of the LPF process and the recycling of acid plant scrubber dust slurry from the smelter. In 1972, a second dryer system was installed to increase capacity."

Jan 1, 1993

By J. R. Meyer, P. L. Dean

"The Department of Mines and Energy is at present investigating the dimension-stone potential of the Nain anorthosite complex. These rocks are known to host occurrences of labradorite, a semiprecious gemstone known for its beautiful play of colours (chatoyance). Test blocks that contain 5% to 18% chatoyant labradorite were extracted from three prospects south of Nain. These have been slabbed and polished for further evaluation.Second-grade labradorite stockpiled around the Grenfell quarry on Tabor Island is also being evaluated as a potential source of aggregate for use in terrazzo tiles, precast concrete and epoxy-backed wall panels.IntroductionThe Nain anorthosite complex consists of approximately 10000 km2 of anorthosite and related basic rocks , which are well exposed along the coast of Northern Labrador (Fig. 1) (Emslie et al., 1972). These rocks have been known for centuries to host deposits of gem-quality labradorite. The chatoyant nature (i.e. the play of colours or labradorescence) of this semiprecious feldspar has been utilized mostly in the making of jewelry and other polished, handcrafted products. In the early sixties, Brinex Limited (now Brinco Limited) attempted larger scale commercial exploitation of labradorite, including use 'as building stone and in polished precast concrete for facings on buildings' (Brummer, 1984). After six years of work, which included market studies, Brinex decided that, at that time, the demand did not warrant further production.In recent years, there has been a dramatic increase in the markets for dimension-stone. In the period from 1980 to 1985, the demand in the United States for granite, much of which is imported, has increased 1735070 (Marble Institute of America, 1986). The dimension-stone industry's remarkable growth rate has, in part, resulted from new technology that makes it easier and faster to quarry and cut stone. This has allowed natural storie to compete with other building materials. Now, it is not only used for exterior cladding and walkways, but also on interior walls and floors, and in home and office furnishings, such as countertops for kitchens and bathrooms, table and desk tops, stairways, window sills, and fireplaces."

Jan 1, 1988

By J. R. Meyer, P. L. Dean

"The Department of Mines and Energy is at present investigating the dimension-stone potential of the Nain anorthosite complex. These rocks are known to host occurrences of labradorite, a semiprecious gemstone known for its beautiful play of colours (chatoyance). Test blocks that contain 5% to 18% chatoyant labradorite were extracted from three prospects south of Nain. These have been slabbed and polished for further evaluation.Second-grade labradorite stockpiled around the Grenfell quarry on Tabor Island is also being evaluated as a potential source of aggregate for use in terrazzo tiles, precast concrete and epoxy-backed wall panels.IntroductionThe Nain anorthosite complex consists of approximately 10000 km2 of anorthosite and related basic rocks , which are well exposed along the coast of Northern Labrador (Fig. 1) (Emslie et al., 1972). These rocks have been known for centuries to host deposits of gem-quality labradorite. The chatoyant nature (i.e. the play of colours or labradorescence) of this semiprecious feldspar has been utilized mostly in the making of jewelry and other polished, handcrafted products. In the early sixties, Brinex Limited (now Brinco Limited) attempted larger scale commercial exploitation of labradorite, including use 'as building stone and in polished precast concrete for facings on buildings' (Brummer, 1984). After six years of work, which included market studies, Brinex decided that, at that time, the demand did not warrant further production.In recent years, there has been a dramatic increase in the markets for dimension-stone. In the period from 1980 to 1985, the demand in the United States for granite, much of which is imported, has increased 1735070 (Marble Institute of America, 1986). The dimension-stone industry's remarkable growth rate has, in part, resulted from new technology that makes it easier and faster to quarry and cut stone. This has allowed natural storie to compete with other building materials. Now, it is not only used for exterior cladding and walkways, but also on interior walls and floors, and in home and office furnishings, such as countertops for kitchens and bathrooms, table and desk tops, stairways, window sills, and fireplaces."

Jan 1, 1988

By D. F. Sangster

"Eight volcanogenic massive sulphide districts in Canada and Japan, ranging in age from Archean to Miocene, were selected for analysis. The study revealed that: {I) each district has an average diameter of 32 km; (2) the districts contain 4 to 20 deposits each, with an average of /2 deposits; (3) the average total base metal content per district is 4.6 million tonnes, with a coefficient of variation of32%; (4) ranked in order of size, the largest deposit in each district contains, on average, 67% of the total metal and the second largest about 13 %. The remaining deposits range downward in decreasing proportions. Empirical observations such as these may be used f or evaluating the undiscovered potential of new districts as well as contributing to a better understanding of the distribution and genesis of this important class of base metal deposits. Previous WorkThe characteristic geological features o f volcanogenic massive sulphide deposits have been described by numerous authors over the past fifteen years and it is now widely accepted that these deposits comprise a major ""deposit-type."" In addition to these geological parameters, however, it is now becoming apparent that volcanogenic massive sulphide deposits show several distinctive grade-tonnage relationships. For example, Singer et al. (1975) demonstrated a slight negative correlation between copper grade and ore tonnage in their sampling of 146 volcanogenic deposits. In a study of 110 Canadian Precambrian deposits of this type, Boldy (1977) showed that the size of the modal deposit is 0.39 million tons, that of the median deposit is 1.40 million tons and the arithmetic average is 6.85 million tons. Moreover, Boldy's data show that the average grade of combined base metals (Cu + Zn + Pb) for each of the se three deposit-sizes is, respectively, 6.25%, 5.35% and 6.47%. Because the lead content of Canadian Precambrian volcanogeni c deposits is most frequently less than 1%, the total metal grade is effectively Cu + Zn . From Figure 2 in Bold y (1977), it can be seen that 83% of the deposits fall in the range of 0.l to 10 million tons ."

Jan 1, 1980

By T. Robson

"A multi-seam underground mining operation employing mechanized room-and-pillar methods provides 35 per cent of Smoky River's annual ROM coal production (2 million tonnes) from the Smoky River coal field. Surface mines provide the balance. Tectonic activity, which has resulted in deformed coal seams and a rugged relief to the area, has provided natural boundaries to discrete mining areas. Coal transportation to the central preparation plant incorporates a 3 km long underground conveying system. The company is committed to efficient resource recovery and a safe and healthy working environment. Introduction The Smoky River Coal operations (SRC) are centered in the Smoky River coal field located in west central Alberta, some 360 km west of Edmonton and 20 km from the Town of Grande Cache (Fig. 1). Combined mining operations produce 2 million tonnes per year run-of-mine coal from which 1.65 million tonnes of high quality, low volatile, coking coal are obtained. The underground mining operation, employing mechanized room-and-pillar methods, provides 35 per cent of SRC's annual ROM coal production (2 million tonnes). Surface mines provide the balance. Tectonic activity has resulted in deformed coal seams and a rugged relief in the area. This has provided natural boundaries to discrete mining areas. Background Exploration of the Smoky River coal field took place over four decades commencing in 1926. McIntyre Mines Limited (parent to Smoky River Coal Ltd.}, commenced development of the property in 1968 having secured a long-term contract for the delivery of coal to Japan. Production of underground coal at Smoky River commenced toward the end of 1969 and has been continuous on the property since that time. Originally, two underground mines were opened. Original planning envisaged the use of room-and-pillar techniques to develop blocks of coal for subsequent extraction by longwall retreat mining. Following initial development, two longwall units were established, the first in November 1970 in No. 5 Mine and the second in February 1971 in No. 2 Mine. Difficulties were experienced on both units, and production commitments could not be achieved. The longwalls were discontinued, and mechanized room-and-pillar was subsequently used for all underground mining."

Jan 1, 1985

By Douglas W. Reeve, Hoc Nghia Tran, David Barham

"In kraft pulp mills, the spent pulping liquor is concentrated and used as fuel in the recovery boiler. Extensive deposits are formed in the upper section of the boiler due to the very high ash content of the fuel and the volatite nature of the ash. Deposits are composed of Na2S04, Na2C03 NaCI, some potassium salts and reduced sulphur compounds. Chloride and potassium salts are enriched in the deposits compared to the smelt due to their greater volatility.Severe corrosion of the superheater tubes in a recovery boiler has been traced to three factors: a non-uniform temperature profile in the flue gas, relatively high operating steam temperatures and high chIoride and potassium concentrations in the fireside deposits.The role of chIoride and potassium in superheater corrosion has been explained by increased Iiquid phase in deposits. Together with corrosion studies, this information has shown that kraft recovery boiler superheater corrosion due to the chloride and potassium enriched deposits can be avoided by proper boiler operation and by judicious superheater and furnace design.IntroductionThis investigation of recovery boiler superheater corrosion was initiated by the discovery of severe corrosion of the final stage superheater in a Canadian closed cycle kraft pulp mill(1,2). Metal wastage leading to tube failure was believed to be due to three major causes : the relatively high operating steam temperatures, the uneven distribution of flue gas temperature across the boiler which created a "" hot spot"" and the high chloride and potassium concentrations in the superheater fire side deposit. The mill responded to the problem by i) lowering the superheater steam temperature from 475°C to 380°C, ii) minimizing the chloride content in the spent pulping liquor, by controlling the NaCI input with recovered bleach plant effluent, and iii) changing metallurgy of a portion of the bottom section of the final stage superheater platens from ferritic steel T-22 (2.25% Cr, 1% Mo) to austenitic steel Incoloy 800H (21% Cr, 32% Ni, 46% Fe, 1.5% Mn, 1% Si, 0.6% Al) (Fig. 1). Details of the superheater corrosion experienced in the closed cycle mil! have been reported in previous papers(l ·2,) ."

Jan 1, 1984

By David Deglon, Martin Harris, Mehdi Safari

"This study investigates the effect of energy/power input on the flotation of a platinum ore in a pilot-scale oscillating grid flotation cell. Oscillating grids generate near ideal hydrodynamic environments, characterised by turbulence which is relatively homogeneous and isotropic. Secondary rougher feed and primary cleaner tail streams were floated in a pilot-scale oscillating grid flotation cell at power inputs from 0 to 2.5 W/kg, using 0.50 and 1.50 mm bubbles. From this study one may conclude that the effect of energy/power input on the flotation rate is strongly dependent on the particle and bubble size. Flotation rates generally increase with increasing particle size and decreasing bubble size. Increasing energy input generally leads to an increase in the flotation rate for finer particles and an optimum flotation rate for intermediate & coarse particles. Optimum conditions for intermediate/coarse platinum ore particles are using small bubbles at low energy inputs, or large bubbles at higher energy inputs. These results suggest that higher energy inputs are generally beneficial for the flotation of platinum ores as these consist predominantly of finer particles (-75 µm) and most industrial flotation applications operate with larger bubbles (1.0-2.0 mm).INTRODUCTIONThere is a considerable body of experimental and theoretical evidence to suggest that energy/power input plays an important role in flotation kinetics, particularly in the finer particle sizes where flotation efficiency is poor (Deglon, 2005). A number of excellent studies into the effect of energy on flotation kinetics have been carried out in impeller stirred cells (Ahmed and Jameson, 1985; Deglon, 2002; Pyke et al., 2003; Newell and Grano, 2006). Investigations using this type of cell have a number of limitations. The impeller influences particle suspension, bubble break-up and agitation in the cell. In addition, turbulence is highly inhomogeneous and anisotropic, with power intensities near the impeller orders of magnitude higher than those found elsewhere in the cell (Deglon, 1998; Koh and Schwarz, 2003; Schubert, 1999, 2008). These limitations have resulted in the development of novel cells for the investigation of energy input."

Jan 1, 2016

"Eastern Canadian thermal coal mined at Minto, New Brunswick, and in western Cape Breton at St. Rose, Inverness County, Nova Scotia, contains 6-8 per cent sulphur. Both coals are high volatile bituminous. types. The Minto coal averages 18 per cent ash, 7 per cent sulphur and has a Btu rating of 11,900 per lb. Pyritic sulphur accounts for 75 per cent of the total sulphur and the remainder is largely organic; the amount of sulphate sulphur is negligible. This means that in a 7 per cent sulphur coal, 2 per cent is organic and 5 per cent pyritic sulphur. Pit-head St. Rose coal contains approximately 10 per cent ash, 7 per cent sulphur and 11 ,800 Btu/lb. The distribution of sulphur is different to that of Minto coal because about 12 per cent sulphate sulphur is present. Thus, a 7 per cent sulphur coal would contain 4 per cent pyritic, 2 per cent organic and 1 per cent sulphate sulphur.The iron sulphides, pyrite and, to a lesser extent, marcassite occur over a wide size range from large sulphur balls to crack fillings, lenses, and individual crystals and framboids. Coarse-grained pyrite and sulphur balls are easily separated during washing. It is the fine grain sizes, intimately mixed with the coal constituents, that are difficult to separate. Quantimet analyses of the fine grains in coal from both localities showed that about 50 per cent were smaller than 30 micron(1).No efforts have been made to wash the Inverness coal of Nova Scotia and in 1980 washing ceased in New Brunswick. Previously, the Minto coal was processed in an antiquated jig circuit which reduced ash from the strip operation run-of-mine value of more than 20 per cent to less than 18. More effective removal of ash and sulphur could clearly be obtained. Laboratory tests on both Minto and St. Rose coal have shown that ash rejection rates of 40 to 50 per cent at yields of 70-80 per cent were possible(2), Little information on sulphur removal was available."

Jan 1, 1981

By B. Loveday, G. W. Delaney, S. Cummins

"Applying DEM to prediction of tumbling mill performance is challenging because several different modes of breakage are active in the process. As our knowledge of breakage and computational capacity improve, it is worth revisiting previous simulation tasks which did not produce a satisfactorily realistic description of a measured process. At SAG 2006, we reported the simulated and measured outcomes of treating a well characterised ore in a 1.2 m diameter mill. This well instrumented, pilot scale mill at the University of KwaZulu-Natal has been combined with some new approaches to ore testing to allow different modes of breakage to be tested. The mill design allows the rate of generation of fine material to be measured in close to real time for autogenous and SAG mill charges. The updated simulation model estimates mass loss with particle evolution and embeds the cumulative damage and breakage.The simulated results are compared with the measured results. Issues such as relating modelling inputs to particle breakage characterisation data and the accuracy of the predictions of the models are discussed."

Jan 1, 2012

By David L. Huston, Wouter Bleeker, Bruce E. Taylor, Ron Cook, Bob Stewart, Elizabeth R. Koopman

"Abstract-Detailed oxygen isotope mapping of rhyolites in and around the Kidd Creek mine indicates that the orebodies are associated with relatively low (<12‰) whole rock values that extend up to 200 m laterally from ore. The zone of low d18O values is overlain stratigraphically by a carapace of higher (>13‰) values that extends up to 1.5 km laterally from and 300 m to 500 m above ore. Immediately above the stratigraphically highest orebody this carapace is cut by a zone of lower d18O values extending from the ore zone. Zones of higher d18O values also occur in massive rhyolite bodies that occur in the footwall of the orebodies.The zone of low d18O values partly coincides with a Na2O depletion anomaly associated with hydrothermal alteration, except that the Na2O depletion anomaly has a greater lateral extent, and the low d18O anomaly extends farther into the stratigraphic hanging wall. These data suggest that d18O mapping may detect hanging wall alteration above massive sulfide bodies more effectively than conventional lithogeochemistry. Zones of high d18O values, which define zones through which large quantities of low-temperature hydrothermal fluids have passed, may also have usefulness in exploration.Oxygen isotope variations at Kidd Creek record three stages of a hydrothermal system that evolved in temperature with time, as follows: (1) an early, low-temperature event that produced rocks with high d18O values, (2) a high-temperature event that produced rocks with lower d18O values, and (3) a later, low-temperature event that also produced rocks with high d18O values. The high d18O sig- nature of the massive rhyolite was recorded during early-stage, low-temperature (<200°C) alteration, and was probably preserved owing to decreases in permeability associated with low-temperature silicification. The low d18O signature of cherty breccia and chloritite was recorded during the thermal peak at >300°C. High d18O values in the carapace above the deposit were recorded as the hydrothermal system waned."

Jan 1, 1995

By B. R. McEwen, A. N. Samis, J. H. Gray

"The Quebrada Blanca Copper Mine is an open pit copper project located at 4200 m elevation in the Chilean Andes. The deposit is a world-class supergene enriched porphyry with a mining reserve of 89 Mt of 1.3% copper. The supergene zone will produce 6.3 Mt of ore per year for more than 15 years to produce 75 000 t of cathode copper per year.This paper will review the project geology the computer model ling of the deposit, the mine planning process and the property production scheduling. With copper production .fixed by the onsite electrowinning capacity, the planning and scheduling aspects to optimize the project NPV will be discussed. Some of the logistics, equipment. personnel and process difficulties of operating a mine at 42()() m elevation will also be described. IntroductionProject DescriptionThe Quebrada Blanca Copper Mine is an open pit copper project located in the northern part of the Chilean Andes. The project is based on the supergene enriched portion of a porphyry deposit which has a mining reserve of 89 million tonnes at 1.3070 copper. Below the enrichment blanket, the protore represents a further resource.All ore will be leached, the higher grade material will be crushed and stacked for thin layer heap leaching, and the lower grade and oxide material will be dump leached as run-of-mine material. Solvent extraction and electrowinning will be used to produce 75 000 tonnes of cathode copper per year. Power will be supplied by a 40 MW on-site diesel generating plant with the waste heat being used for process heating. The leaching operation will operate in excess of 15 years and may be followed by open pit mining and conventional ore concentration of the underlying primary sulphide mineralization.Because of the dry location water will be piped 37 km from a ground water source at the Salar de Michincha. Water requirements will be approximately 1.5 million m3/year. The operation will eventually employ approximately 550 people on a 7-day-on, 7-day-off rotation with two twelve-hour shifts per day with an on-site camp. Busing will be provided to the port city of Iquique."

Jan 1, 1994

By Peter J. Barnard

Mitochondria play a key role in the regulation of apoptosis (cell death) and in diseases characterised by abnormal apoptotic responses such as cancer. Mitochondrial membrane permeabilisation (MMP), regulated by the mitochondrial permeability transition pore complex, is widely accepted as being central to the process of cell death. As a result there has been considerable recent interest in targeting mitochondrial cell death pathways in the development of new chemotherapeutic agents.(1) There is potential to overcome the two overriding problems in cancer chemotherapy?the common occurrence of drug-resistant tumour cells and the lack of selectivity of cancer drugs in differentiating between tumour cells and normal tissues. Significantly, carcinoma cells have an elevated mitochondrial membrane potential relative to normal cells and lipophilic cations are concentrated within mitochondria in response to mitochondrial membrane potentials. There is potential for the selective targeting to tumour cells with compounds having optimal lipophilic-hydrophilic character. Research stemming from the early 1980?s points to two distinct classes of Au(I) phosphine antitumour agents where an antimitochondrial mode of action has been implicated: (i) neutral linear two-coordinate Au(I) complexes such as triethylphosphinegold(I) chloride and the tetraacetylthioglucose gold(I) phosphine complex, Auranofin; (ii) cationic tetrahedral bis-chelated Au(I) phosphine complexes related to [Au(dppe)2]+.(2) Recently it has been reported that Auranofin, at submicromolar concentrations, induces MMP observed as mitochondrial swelling and dissipation of membrane potential.(3, 4) Both events are completely inhibited by cyclosporin-A, the specific inhibitor of MMP. The permeability changes were shown to occur at concentrations associated with the selective inhibition of mitochondrial thioredoxin reductase.(3) Auranofin is a potent and specific inhibitor of this enzyme due to Au(I) binding to the active-site selenol group.(5) The redox state of mitochondrial thiols may be critical in the control of MMP.(3) In general, swelling is stimulated by thiol blocking or oxidising agents and is prevented by thiol reducing agents.(1) Mitochondrial thioredoxin reductase may play an import role in the redox control of the permeability of mitochondrial membranes.(3) Our interest is in investigating the antitumour potential of Au(I) phosphine compounds using a number of different approaches. In recent work we have evaluated a series of hydrophilic analogs of [Au(dppe)2]+ containing pyridylphosphine ligands which have demonstrated greater tumour selectivity than the parent compound. To investigate the possible antimitochondrial mode of action we are studying the effect of [Au(dppe)2]+ and related compounds on isolated rat liver mitochondria. To assess whether the lipophiliccationic nature of the compounds determines the antitumour activity, we have synthesized a series of novel Au(I) complexes based on heterocyclic carbene rather than phosphine ligands. The similar chemistry and structural features of the two classes of complexes allow us to assess whether the phosphine ligands are essential for the antitumour properties.

Oct 1, 2003